Evidence map›Paper›PMID 41035178›Full record

ArticleThe New phytologist2025

Clathrin-mediated endocytosis regulates root endodermal suberization via ROS.

Javier Martinez Pacheco, Wolfgang Busch

Abstract read
In one paragraph

Article in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Javier Martinez PachecoPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, San Diego, CA, 92037, USA.ORCID https://orcid.org/0000-0003-2326-4933
Wolfgang BuschPlant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, San Diego, CA, 92037, USA.ORCID https://orcid.org/0000-0003-2042-7290

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
NCI NIH HHS P30 CA014195NIA NIH HHS P30 AG068635
6 · The paper itself

Abstract

Endomembrane trafficking (ET) plays a crucial role in plant adaptation to environmental stresses, yet its involvement in endodermal root suberization remains poorly understood. Here, we show that disruption of clathrin-mediated endocytosis (CME) or canonical exocytosis led to an ectopic suberin deposition in the Arabidopsis root endodermis toward the root tip. Genetic disruption of endocytosis phenocopied the effects of the CME inhibitor ES9-17, while genetic disruption of clathrin-independent endocytosis led to reduced suberization, suggesting distinct, pathway-specific roles in regulating suberin deposition. Ectopic suberization upon CME inhibition required the CIFs-SGN3-SGN1-RBOHF/D signaling axis, independent of abscisic acid. Notably, CME disruption led to the accumulation of RBOHF in the plasma membrane, driving NADPH oxidase-dependent H

Indexed as

ArabidopsisClathrinEndocytosisPlant RootsReactive Oxygen SpeciesArabidopsis ProteinsCell MembraneExocytosisHydrogen PeroxideLipidsNADPH OxidasesSignal TransductionArabidopsis ProteinsClathrinHydrogen PeroxideLipidsNADPH OxidasesReactive Oxygen SpeciessuberinArabidopsisendocytosisendodermisROSsuberin

Identifiers

PMID41035178
PMCPMC12582552

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.