Evidence map›Paper›PMID 41035043›Full record

ArticleBMC research notes2025

Continuous passive motion for prevention of ankle contracture and muscle loss in mechanically ventilated ICU patients.

Chen-Chun Lin, Yi-Jia Lin, Hsien-Chun Wang, Wei-Chun Hsu

Registry-linked trialAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06944431 (Application of Continuous Passive Motion to Prevent Ankle Contracture and Muscle Loss in the Mechanically Ventilated Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06944431 nacompletednot on this map

Application of Continuous Passive Motion to Prevent Ankle Contracture and Muscle Loss in the Mechanically Ventilated Patients

TypeinterventionalSponsorShin Kong Wu Ho-Su Memorial HospitalRan2024 to 2025Enrolled12ConditionsJoint Contracture, Mechanical Ventilation, ICU-acquired Weakness, Critical IllnessArmsContinuous Passive Motion (CPM)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chen-Chun LinGraduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.
Yi-Jia LinGraduate Institute of A.I. Cross-disciplinary Technology, National Taiwan University of Science and Technology, Taipei, Taiwan.
Hsien-Chun WangDepartment of Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 111, Taiwan.
Wei-Chun HsuGraduate Institute of Applied Science and Technology, Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, 106, Taiwan. wchsu@mail.ntust.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis prospective, within-patient controlled study aimed to evaluate the effects of continuous passive motion therapy on ankle mobility and muscle morphology in mechanically ventilated ICU patients-a population vulnerable to ICU-acquired weakness and joint contractures.

resultsTwelve ventilated patients completed the protocol. The ankle treated with continuous passive motion therapy showed a significant improvement in dorsiflexion passive range of motion, increasing from 9.90° [IQR: 6.20-13.15°] to 12.99° [IQR: 9.07-20.20°] (p = 0.004), while the control ankle showed no significant change (p = 0.388). The increase in passive range of motion was significantly greater in the continuous passive motion treated ankle compared with the control (4.18° vs. 0.42°, p = 0.028). No significant between-limb differences were observed in tibialis anterior muscle thickness, cross-sectional area, or pennation angle. Echointensity increased in both limbs without group differences. These findings suggest that continuous passive motion can be applied as an early intervention to preserve ankle mobility in ICU patients. Although short-term muscle morphology changes were not significant, passive range of motion gains suggest continuous passive motion may help prevent contractures and support early rehabilitation during critical illness.

trial registrationClinicalTrials.gov NCT06944431, registered on April 25, 2025. Retrospectively registered.

Indexed as

Ankle JointContractureMotion Therapy, Continuous PassiveMuscle, SkeletalRespiration, ArtificialAgedCritical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesRange of Motion, ArticularAnkle contractureContinuous passive motionICU-acquired weaknessMuscle ultrasound

Identifiers

PMID41035043
PMCPMC12486782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.