Evidence map›Paper›PMID 41035041›Full record

ArticleAddiction science & clinical practice2025

Design of a cluster-randomized, hybrid type 1 effectiveness-implementation trial of a care navigation intervention to increase substance use disorder treatment engagement: study protocol.

Theresa E Matson, Mia A Navarro, Abisola Idu, Jennifer F Bobb, Briana M Patrick, Rebecca Phillips, Tyler D Barrett, Fernanda S Rossi, Noa Krawczyk, Rachael Doud and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction science & clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06729957 (Addressing Barriers to Care for Substance Use Disorder Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06729957 naactive not recruitingnot on this map

Addressing Barriers to Care for Substance Use Disorder Trial (Center for Dissemination and Implementation At Stanford, Research Component #3)

TypeinterventionalSponsorKaiser PermanenteRan2024 to 2026Enrolled360ConditionsDrug Use Disorders, Alcohol-Related Disorders, Substance Use Disorder (SUD)ArmsCare Navigation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Theresa E MatsonKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA. tessa.e.matson@kp.org.
Mia A NavarroCenter for Dissemination and Implementation at Stanford, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, USA.
Abisola IduKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Jennifer F BobbKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Briana M PatrickCenter for Dissemination and Implementation at Stanford, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, USA.
Rebecca PhillipsKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Tyler D BarrettKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Fernanda S RossiCenter for Dissemination and Implementation at Stanford, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, USA.
Noa KrawczykCenter for Opioid Epidemiology and Policy, Department of Population Health, New York University Grossman School of Medicine, New York, USA.
Rachael DoudKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Kristine RogersKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Chayna J DavisKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.
Ryan CaldeiroKaiser Permanente Washington Mental Health and Wellness Service, Seattle, USA.
Joseph E GlassKaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Ste. 1300, Seattle, WA, 98101, USA.

Funding

Transforming health equity rhetoric to rigor: Development and validation of a novel measure assessing health equity in implementation of health interventionsP50DA054072 · NIDA · STANFORD UNIVERSITY · PI Mark P McGovern · 2022 to 2026
$18.1M
Digital treatments for opioids and other substance use disorders (DIGITS) in primary care: Observational Analysis of Adaptions to the InterventionR01DA047954 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI GLASS, JOSEPH EDWIN · 2019 to 2023
$3.9M
Beyond Treatment Initiation: Enhancing Opioid Use Disorder Care Transitions Across Health System TouchpointsK01DA055758 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Noa Krawczyk · 2023 to 2026
$722k
NIDA/NIH K01DA055758NIDA NIH HHS P50 DA054072NIDA NIH HHS R01 DA047954
6 · The paper itself

Abstract

backgroundPractical and motivational barriers can deter people from engaging in substance use disorder (SUD) treatment, even those who seek treatment. Care navigation is a psychosocial intervention that seeks to facilitate patients' timely access to care by identifying and intervening upon barriers. Few trials have tested the effectiveness of care navigation when embedding in real-world healthcare, and no trials have studied the process of implementing care navigation into clinical practice. This protocol describes a study that will evaluate whether care navigation can increase treatment engagement among patients seeking SUD treatment.

methodsThe Addressing Barriers to Care for Substance Use Disorder (ABC-SUD) study is a hybrid type I cluster-randomized effectiveness-implementation trial. It is conducted in a mental health access center of an integrated healthcare system in Washington state. Within this center, licensed mental health clinicians assess patient needs and use shared decision-making to establish SUD treatment plans for patients (usual care). This study tests whether an added care navigation intervention can improve patient engagement in SUD treatment. Care navigation begins after a treatment plan is made and provides up to 7 weeks of support focused on enhancing patient motivation to initiate and engage in treatment, problem-solving barriers (e.g., transportation logistics), and accommodating patient preferences (e.g., preferred language of care, cultural preferences). This trial uses a two period, two sequence crossover design. Clinicians are randomized to offer care navigation to patients during the first or second study period (i.e., clinicians are assigned to an initial study condition and switch conditions halfway through the trial). Care navigation is implemented with several strategies: leadership engagement, clinical workflow specifications, electronic health record (EHR) tools, training, performance improvement, and electronic learning collaborative. The primary outcome-obtained from EHRs and insurance claims-is engagement in SUD treatment, defined as ≥3 SUD treatment visits within 48 days of a treatment plan. This study uses standardized measures of implementation climate and outcomes to examine mechanisms with which the intervention strategies exert their impact on implementation and effectiveness outcomes. DISCUSSION: The ABC-SUD study will test whether care navigation improves SUD treatment engagement while concurrently generating information about its implementation in healthcare.

trial registrationThis study was prospectively registered at www. CLINICALTRIALS: gov (NCT06729957) on December 9, 2024.

Indexed as

Patient NavigationPatient ParticipationSubstance-Related DisordersHealth Services AccessibilityHumansRandomized Controlled Trials as TopicWashingtonCare navigationCrossover trialImplementationProtocolSubstance use disorder

Identifiers

PMID41035041
PMCPMC12486859

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.