Evidence map›Paper›PMID 41035038›Full record

ArticleJournal of nanobiotechnology2025

Sodium alginate piezoelectric hydrogel loaded with extracellular vesicles derived from bone marrow mesenchymal stem cells promotes repair of Achilles tendon rupture.

Ao Duan, Bingqing Lin, Zhencheng Xiong, Xiaolong Shao, Wenzheng Liu, Renliang Zhao, Xiangtian Deng, Chaoyi Zhang, Dong Wang, Zilu Ge and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ao Duan *Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Bingqing Lin *College of Materials and Energy, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Zhencheng Xiong *Trauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaolong Shao *Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.
Wenzheng LiuTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Renliang ZhaoTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiangtian DengTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chaoyi ZhangTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Dong WangTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zilu GeTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaoran HuCollege of Materials and Energy, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China.
Wei LinDepartment of Gynecology, West China Second Hospital, Sichuan University, Chengdu, 610041, China.
Shouye HuDepartment of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China. hushouye2021@126.com.
Guanglin WangTrauma Medical Center, Department of Orthopedics Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. wglfrank@wchscu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accelerated repair of Achilles tendon rupture and prevention of re-rupture continue to pose significant technical challenges in orthopedic surgery and rehabilitation. Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells exhibit substantial therapeutic potential for various degenerative diseases and tissue regeneration. However, the use of EVs alone for repairing ruptured Achilles tendons requires multiple invasive administrations, such as repeated injections, to maintain a therapeutic effect, which increases patient discomfort and the risk of infection. In this study, we innovatively combined EVs with sodium alginate-based piezoelectric hydrogel (SPH) to develop SPH-EVs. By leveraging the slow degradation of SPH in vivo, SPH-EVs enable sustained-release of EVs while generating electrical stimulation, ensuring that an effective therapeutic concentration is maintained at the Achilles tendon fracture site. Additionally, the integrated near-field communication (NFC) module within SPH-EVs allows for real-time monitoring of rehabilitation exercise intensity in the affected area, guiding patients to conduct rehabilitation training within a safe range and minimizing the risk of re-rupture.

Indexed as

Achilles TendonRuptureTendon InjuriesAlginatesAnimalsBehavior, AnimalBiocompatible MaterialsBone Marrow CellsCell MovementCell ProliferationCells, CulturedElectric Stimulation TherapyExtracellular VesiclesHydrogelsMaleMesenchymal Stem CellsAlginatesBiocompatible MaterialsHydrogelsAchilles tendon ruptureMotion monitoringRepairSodium alginate piezoelectric hydrogelSPH-EVs

Identifiers

PMID41035038
PMCPMC12486638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.