Evidence map›Paper›PMID 41035034›Full record

ArticleJournal of translational medicine2025

Gastric microbiome in gastric cancer sequence depicts diverse microbial structures associated with cancer risk and prognosis.

Tsubasa Shimogama, Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Yusuke Honzawa, Toshiro Fukui and 1 more

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In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tsubasa ShimogamaThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Tomomitsu TaharaThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan. tahara.tom@kmu.ac.jp.ORCID 0000-0002-3474-8274
Takuya ShijimayaThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Jumpei YamazakiTranslational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Sanshiro KobayashiThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Naohiro NakamuraThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Yu TakahashiThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Takashi TomiyamaThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Yusuke HonzawaThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Toshiro FukuiThird Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Makoto Naganuma

Funding

Japan Society for the Promotion of Science 22K08089
6 · The paper itself

Abstract

objectiveIncreasing evidence indicated substantial involvement of non-Helicobacter pylori microbiota in gastric tumorigenesis. We aimed to elucidate detailed relationship of microbiome dynamics between two different steps in gastric cancer (GC) such as cancer initiation and progression, and assessed their associations with clinicopathological and molecular changes.

methodsWe systemically characterized gastric microbiome during GC initiation and progression using 944 biopsies from primary GC, non-cancerous gastric mucosa from both GC and non-cancer subjects. The association between specific microbial characteristics and GC risk, prognosis and molecular changes such as TP53 mutation, DNA methylation and telomere shortening were also evaluated.

resultsMicrobial α-diversity in the gastric mucosa was decreased in relation to the GC occurrence, while it increased in primary GC tissue. Such paradoxical change was also observed in specific groups of bacteria during GC occurrence and its progression. GC risk-related microbiome was associated with differentiated GC, severe intestinal metaplasia, associated DNA methylation and telomere shortening, while GC tissue-specific microbiome was associated with more aggressive features of GC and TP53 mutation status.

conclusionsOur findings suggested the different role of non-Helicobacter pylori microbiota in GC initiation and progression steps.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaStomachStomach NeoplasmsAgedDNA MethylationFemaleGastric MucosaHumansMaleMiddle AgedMutationPrognosisRisk FactorsTumor Suppressor Protein p53Tumor Suppressor Protein p53DNA methylationGastric cancerMicrobiotaPrognosisRisk

Identifiers

PMID41035034
PMCPMC12487302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.