ArticleJournal of translational medicine2025
Interplay of axon regeneration genes and immune infiltration in spinal cord injury.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Screening of signaling pathways and hub genes in Guillain-Barré syndrome based on bioinformatics and machine learning.BMC neurology · 2026Article
- Nanoengineered Niclosamide as a Microenvironment Modulator for Spinal Cord Regeneration: A Hypothetical Roadmap Toward Brain/Head Transplant Feasibility.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundSpinal Cord Injury (SCI) impacts neural function and regeneration. This study aimed to identify key axon regeneration genes in SCI and their correlations with immune infiltration and SCI subtyping.
methodsGene expression profiles of 30 sham-operated mice and 29 SCI mice were obtained from GSE5296, GSE47681, and GSE93561 datasets. A PPI network of axon regeneration genes was constructed. Consensus clustering classified SCI subtypes. Differential expression analysis identified genes associated with SCI and its subtypes. Immune infiltration was assessed. WGCNA identified key genes. Potential drugs targeting hub genes were explored. An SCI mouse model was established and subjected to HE staining to assess pathological changes. The dysregulation of five key axon regeneration-related genes was validated in mouse spinal cord tissues using qRT-PCR and Western blotting.
resultsWe identified 2,971 genes associated with SCI, including 19 axon regeneration-related genes, and 144 differentially expressed transcription factors, with Jun being highly interconnected. Significant alterations in immune cell abundance correlated with axon regeneration genes. Consensus clustering stratified SCI samples into two subtypes. WGCNA identified 21 hub genes associated with SCI subtypes. Drug-gene interaction analysis identified Itgam and Ptprc as potential therapeutic targets. Validation experiments showed significant upregulation of Fn1, Sdc1, and Cspg4, and downregulation of Col4a1 and Lamb1 in the SCI model group compared to controls.
conclusionsOur study elucidates the interplay among axon regeneration genes, immune infiltration, and transcriptional regulation in SCI. Validation experiments confirmed the dysregulation of key axon regeneration-related genes in SCI mice, supporting their role in SCI pathology.
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