ArticleBMC biology2025
Deciphering the origins of guanylate-binding proteins in mammals (Monotreme, Marsupials and Placentals).
Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The evolutionary history of IGKC in mammals reveals ancient duplications and remarkable divergence in lagomorphs.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundGuanylate-binding proteins (GBPs) belong to the large guanosine triphosphatases (GTPases) family and have specialised in host defence in vivo against a broad spectrum of invading pathogens. This ancient evolutionary group of genes was first studied in humans and rodents, but its evolution remained largely unknown for nearly 20 years. In recent years, more studies have emerged deepening the knowledge of GBP evolution in specific mammalian groups: Primates, Tupaia, Muroids (Rodents), Bats and Lagomorphs.
resultsHere, we aimed to present a comprehensive analysis of mammals GBP evolution. Our phylogenetic analysis demonstrates that mammals' GBPs share a common ancestor and that each major mammalian group has evolved a specific GBP repertoire. Two Monotreme GBP groups, GBP8 and GBP9, cluster independently in the phylogenetic tree and do not share the synteny of the other mammalian GBP genes. The other two Monotreme GBP groups, GBP1/2/3/5 and GBP4/6/7, are at the basal position of the main mammalian groups. Marsupials have two GBP groups, Marsupial GBP1/2/3/5, basal to Placental GBP1/2/3/5, and Marsupial GBP4/6/7, basal to Placental GBP4/6/7. Marsupial GBP1/2/3/5 can be subdivided into three sub-groups, similarly to what is observed in the Placental GBPs, whereas Marsupial GBP4/6/7 underwent several duplication events across species. We also examined the GBP tissue expression pattern in Monodelphis domestica and found that GBPs are ubiquitously expressed in most tissues, with some differences. Noteworthy was the presence of GBP transcripts in late foetal and newborn opossum tissues.
conclusionsThe GBP genes revealed a distinct evolutionary pattern in each main mammalian group. Phylogenetic analysis shows that Monotremes and Marsupials have specific GBPs. Particularly intriguing is the presence of GBP8 and GBP9 only in Monotremes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.