ArticleBMC musculoskeletal disorders2025
Association between sarcopenia, its components, and osteoporosis in the FRISBEE cohort.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sarcopenia risk in women with postmenopausal osteoporosis: a SARC-F-based assessment.Turkish journal of medical sciences · 2026Article
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14 authors.
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Abstract
BACKGROUND &
objectivesBone and muscle diseases are both highly prevalent in aging adults, but results from previous studies examining the relationship between sarcopenia and its components with osteoporosis are inconsistent. This study aimed to investigate the associations between sarcopenia, its components, and osteoporosis in older women from the Fracture RISk Brussels Epidemiological Enquiry (FRISBEE) cohort. Additionally, it explored the relationship between sarcopenia components and trabecular bone score (TBS).
methodsThis study is based on cross-sectional data from the FRISBEE cohort, involving 3560 community-dwelling postmenopausal women initially included between 2007 and 2013. Consecutively included participants were reassessed 10 years after inclusion, with evaluations including body composition by dual-energy X-ray absorptiometry (DXA), a medical questionnaire, and a comprehensive geriatric assessment. The diagnostic criteria for sarcopenia were: low muscle mass (appendicular skeletal muscle index [ASMi] < 5.5 kg/m2), low muscle strength (< 16 kg), and low gait speed (≤ 0.8 m/s), according to the European Working Group on Sarcopenia in Older People (EWGSOP2). Osteoporosis was defined using the extended criteria proposed by the National Bone Health Alliance Working Group.
resultsAmong the 500 women included, with a median age of 77.4 years (74.7–81.8), 178 (35.6%) were diagnosed with osteoporosis. Significant correlations were shown between sarcopenia, its components, and bone mineral density (BMD), as well as with TBS. The strongest correlations were between handgrip strength and distal forearm BMD (r = 0.27; p < 0.001), and between ASMi and total hip BMD (r = 0.36; p < 0.001). Significant differences were observed according to osteoporotic status: handgrip strength, Short Physical Performance Battery (SPPB) test, gait speed, and ASMi were significantly lower in participants with osteoporosis (p < 0.001). After adjustment for all covariates, handgrip strength and gait speed were still significantly associated with osteoporosis with an odds ratio of 0.92 (0.88–0.97) and 0.33 (0.11–0.96), respectively. A significant association was also observed between sarcopenia and osteoporosis with a crude odds ratio of 3.88 (1.97–7.85).
conclusionsSarcopenia and its components, particularly handgrip strength and gait speed were significantly associated with osteoporosis. TBS was also significantly associated with all sarcopenia components. These findings may be helpful when evaluating bone health and fracture risk in clinical practice.
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