Evidence map›Paper›PMID 41034793›Full record

Trial reportBMC cancer2025

Combined technology-enhanced home exercise and acupressure (TEHEplus) program on symptoms among cancer patients receiving immunotherapy: a feasibility study.

Nada Lukkahatai, Chitchanok Benjasirisan, Aomei Shen, Junxin Li, Sarah Allgood, Frank Thomas, Artyom Karyukin, Jennifer Y Sheng, Jessica Engle, Ta-Ya Lee and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03576274 (Effectiveness of the Combined Technology-enhanced Home Exercise Program and Other Non-pharmacological Interventions on Fatigue, Physical Function and Well-being Among Cancer Survivors), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03576274 nacompletednot on this map

Effectiveness of the Combined Technology-enhanced Home Exercise Program and Other Non-pharmacological Interventions on Fatigue, Physical Function and Well-being Among Cancer Survivors

TypeinterventionalSponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsRan2019 to 2024Enrolled110ConditionsCancer-related Problem/Condition, Exercise, AcupressureArmsTechnology Enhanced Home Exercise (TEHE), Auricular Point Acupressure (APA), Mindfulness body scan (MBI)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nada LukkahataiSchool of Nursing, Johns Hopkins University, Baltimore, MD, USA. nada.lukkahatai@jhu.edu.ORCID http://orcid.org/0000-0003-3820-1812
Chitchanok BenjasirisanSchool of Nursing, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6465-0721
Aomei ShenTianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin Medical University Ministry of Education, Tianjin, China.ORCID http://orcid.org/0000-0003-0569-8746
Junxin LiSchool of Nursing, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9798-5456
Sarah AllgoodSchool of Nursing, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-0259-6613
Frank ThomasSchool of Nursing, Johns Hopkins University, Baltimore, MD, USA.
Artyom KaryukinSchool of Nursing, Johns Hopkins University, Baltimore, MD, USA.
Jennifer Y ShengJohns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4513-4235
Jessica EngleJohns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4711-7324
Ta-Ya LeeJohns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Leorey N SaliganSchool of Nursing, Rutgers, The State University of New Jersey, Newark, NJ, USA.ORCID http://orcid.org/0000-0001-9481-7836

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
NCI NIH HHS NCI CCSG P30 CA06973NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

backgroundCancer patients receiving immunotherapy often experience symptoms impacting their well-being. The present study aimed to develop and test the feasibility of a 12-week Technology-Enhanced Home Exercise and acupressure (TEHEplus) program to improve symptoms (fatigue, pain, sleep, anxiety, depression), social functioning, physical performance, and serum biomarkers (brain-derived neurotrophic factor, heat shock protein 90 levels.)

methodsA two-phase design was employed. Phase 1 involved program development; Phase 2 was a pilot feasibility study. Participants with solid tumor cancers were recruited from cancer centers in Maryland and randomly assigned to four groups: Usual Care Control (UC), Technology-Enhanced Home Exercise (TEHE) alone, Acupressure alone (ACU), and TEHEplus. Feasibility was measured by enrollment duration, intervention adherence, and daily survey response rates. Outcomes were measured at baseline and program completion.

resultsIn phase 1, four participants (age 56-82) provided feedback on online training, smartphone application, intervention duration, and outcome measures. In Phase 2, 40 participants (10 per group) were recruited over 12 months, with 43% (n = 17) completing all daily surveys. TEHEplus participants achieved 50% of exercise goals, and 78% adhered to the acupoint recommendations. TEHEplus participants showed significant improvements in fatigue (p = 0.02), pain inference (p = 0.30), and social functioning (p = 0.03); TEHE participants improved only in social functioning (p = 0.03).

conclusionTEHEplus is feasible and shows promise for symptom alleviation. Preliminary findings suggest potential benefits in symptom management and functional outcomes. However, further studies with larger and more diverse samples are warranted to explore its efficacy and generalizability.Further studies with larger, more diverse populations are needed to confirm its efficacy. TEHEplus may enhance symptom management and improve functional outcomes for cancer survivors undergoing immunotherapy.

trial registrationClinicalTrials.gov ID NCT03576274 Trial Registration Date: 06/07/2018.

Indexed as

AcupressureExerciseExercise TherapyImmunotherapyNeoplasmsAgedAged, 80 and overFatigueFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsQuality of LifeAcupressureCancerExerciseImmunotherapyMobile health

Identifiers

PMID41034793
PMCPMC12490062

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.