Evidence map›Paper›PMID 41034780›Full record

ArticleBMC pregnancy and childbirth2025

First trimester maternal serum MicroRNA expression and pre-eclampsia: a retrospective nested case-control study.

Paula L Hedley, Severin Olesen Larsen, Karen R Wøjdemann, Anne-Cathrine Shalmi, Sophie Placing, Line Rode, Anne Cathrine Gjerris, Karin Sundberg, Ann Tabor, Michael Christiansen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paula L HedleyDepartment for Congenital Disorders, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark. phy@ssi.dk.
Severin Olesen LarsenDepartment for Congenital Disorders, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark.
Karen R WøjdemannDepartment of Gynecology and Obstetrics, Bornholm Sygehus, Rønne, Bornholm, 3700, Denmark.
Anne-Cathrine ShalmiDepartment of Obstetrics, Hillerød Sygehus, Hillerød, 3400, Denmark.
Sophie PlacingDepartment for Congenital Disorders, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark.
Line RodeCenter of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 2100, Denmark.
Anne Cathrine GjerrisDepartment of Obstetrics, Hillerød Sygehus, Hillerød, 3400, Denmark.
Karin SundbergCenter of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 2100, Denmark.
Ann TaborCenter of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, 2100, Denmark.
Michael ChristiansenDepartment for Congenital Disorders, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous circulating microRNAs (miRNAs) have been detected in maternal blood. Initial studies in third trimester demonstrated differential miRNA expression profiles between uncomplicated pregnancies and pregnancies complicated by pre-eclampsia (PE). Recently, studies in first trimester have shown similar differential profiles, however, these studies were often under-powered.

methodsWe conducted a nested case-control study, in which serum samples, taken between 10 and 14 weeks gestation, were obtained from 413 singleton pregnant women, 126 of which later developed PE. Total RNAs were purified and a selection of 46 miRNAs plus two miRNA controls were quantitated by real time quantitative PCR.

resultsSeven of the miRNAs, hsa-miR-181b-5p, -323a-3p, -518b, -363-3p, -20a-5p, -29a-3p, and - 142-3p, could differentiate between uncomplicated pregnancies and pregnancies which develop PE, but only a single miRNA, hsa-miR-363-3p, could differentiate between mild and severe PE. A combination of all seven differentiating miRNAs was the best at discriminating between PE and uncomplicated pregnancies (AUC = 0.879).

conclusionFirst trimester maternal serum miRNA expression profile could differentiate between uncomplicated pregnancies and pregnancies complicated by PE. These circulating miRNA markers have the potential to improve risk assessment of PE in the first trimester, weeks before the onset of symptoms.

Indexed as

MicroRNAsPre-EclampsiaPregnancy Trimester, FirstAdultBiomarkersCase-Control StudiesFemaleHumansPregnancyRetrospective StudiesBiomarkersMicroRNAsCirculating MicroRNAFirst trimesterPre-EclampsiaQuantitative Real-Time PCR

Identifiers

PMID41034780
PMCPMC12486713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.