ArticleBMC pregnancy and childbirth2025
Associations between triglyceride-glucose index in the early trimester of pregnancy and adverse pregnancy outcomes.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Association between glycolipid metabolism 7 factors (GLM7) and pregnancy loss in women aged 18-35 years: evidence from NHANES 2009-2018.Lipids in health and disease · 2026Article
- Distinct pregnancy challenges in PCOS women undergoing IVF/ICSI with singleton and twin births: a propensity-matched analysis.Journal of ovarian research · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveAdverse pregnancy outcomes seriously affect the health of pregnant women and fetuses. However, no typical symptoms occur in the early trimester of pregnancy. The present study aimed to evaluate the predictive efficacy of the triglyceride-glucose (TyG) index in the early trimester for adverse pregnancy outcomes.
methodsA total of 2,847 singleton pregnant women without preconception diabetes and hypertension were included. The multivariate logistic regression model was used to explore the relationship between the TyG index and pregnancy adverse outcomes.
resultsTyG index in the early trimester of pregnancy was an independent risk factor for gestational diabetes mellitus (GDM) (OR = 2.16, 95%CI 1.63-2.87, P < 0.001) and gestational hypertension (GH) (OR = 1.95, 95%CI 1.14-3.33, P < 0.05). The optimal cut-off point of the TyG index for GDM was 8.345 (sensitivity 53.33%, specificity 70.19%), and the area under the curve (AUC) was 0.630 (95% CI 0.600-0.660, P < 0.001). The optimal cut-off point of the TyG index for predicting GH was 8.425 (sensitivity 46.67%, specificity 76.19%), and the AUC was 0.622 (95%CI 0.578-0.665, P < 0.001). The restricted cubic spline (RCS) curve showed that there was a significant linear association between the early trimester TyG index and GDM or GH when it was > 8.167.
conclusionThe first-trimester TyG index is closely associated with the development of GDM and GH among pregnant women. An elevated TyG index in early trimester pregnancy may help predict the risk of GDM and GH, which provides an effective marker for us to prevent and detect adverse pregnancy outcomes in the early stage.
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