Evidence map›Paper›PMID 41034731›Full record

ArticleBMC pregnancy and childbirth2025

The impact of hypertensive disorders of pregnancy on perinatal outcomes in twin pregnancies: a national multi-center cohort study.

Zhoushan Feng, Chunhong Jia, Xiao-Mei Tong, Zheng He, Chunxia Yang, Wei Shen, Yueqin Ding, Jin Liu, Qiong Meng, Aiqin Zhang and 15 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Zhoushan Feng *Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chunhong Jia *Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiao-Mei Tong *Department of Pediatrics, Peking University Third Hospital, Beijing, China.
Zheng He *Department of Neonatology, Sichuan jinxin xinan women and children's hospital, Chengdu, China.
Chunxia Yang *Department of Neonatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Wei Shen *Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, China.
Yueqin Ding *Department of Neonatology, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.
Jin Liu *Department of Neonatology, First Affiliated Hospital of Shaoyang University, Shaoyang, China.
Qiong Meng *Department of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Aiqin Zhang *Department of Neonatology, Cangzhou People's Hospital, Cangzhou, China.
Hong Jiang *Department of Neonatology, Affiliated Hospital of Yanan university, Yan an, China.
Wenkang Yan *Department of Neonatology, Huizhou Central People's Hospital, Huizhou, China.
Jianwu Qiu *Department of Neonatology, The Affiliated Yue Bei People's Hospital of Shantou University Medical College, Shaoguan, China.
Xian Wei *Department of Neonatology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, China.
Yayu Zhang *Department of Neonatology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Xiaobo Lin *Department of Neonatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Lijun Liu *Department of Neonatology, The Third Staff Hospital of Baogang Group Baotou, Baotou, China.
Ya Jin *Department of Neonatology and Pediatrics, Jinan University First Affiliated Hospital, Guangzhou, China.
Youfen Wei *Department of Neonatology, Lanzhou University Second Hospital, Lanzhou, China.
Weixing Zhang *Department of Neonatology, Xinxiang Central Hospital, Xinxiang, China.
Xiufang Yang *Department of Neonatology, Zhongshan City People's Hospital, Zhongshan, China.
Yitong Wang *Department of Neonatology, Binhaiwan Central Hospital of Dongguan, Dongguan, China.
Yangfan Cai *Department of Neonatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Fan Wu *Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. gdwufan@126.com.
Qiliang Cui *Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. gycuiqiliang@126.com.

Funding

the Guangdong Basic and Applied Basic Research Foundation 2024A1515220100the National Natural Science Foundation of China 82402011the Plan on Enhancing Scientific Research in GMU GMUCR2025-01003
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP) significantly impact infant outcomes. However, evidence regarding HDP's effects on twin pregnancies remains limited and poorly characterized. This study aimed to investigate the impact of HDP on perinatal outcomes and neonatal complications in twin pregnancies.

methodsData were collected from 22 medical centers across 12 Chinese provinces between January 2018 and December 2020. The primary variable of interest was HDP (including gestational hypertension and preeclampsia). Perinatal outcomes and neonatal complications were systematically assessed using multivariable logistic regression, propensity score matching, and overlap weighting (OW).

resultsAmong 6,307 twin pregnancies, 1,013 cases (16.1%) were diagnosed with HDP. HDP significantly increased the likelihood of preterm birth (2.68 [2.27-3.15]

conclusionsHDP increases adverse perinatal and neonatal outcomes in twins. Therefore, careful monitoring and management are imperative for mothers diagnosed with HDP carrying twins to mitigate these adverse outcomes.

trial registrationNA.

Indexed as

Hypertension, Pregnancy-InducedPregnancy OutcomePregnancy, TwinAdultChinaCohort StudiesFemaleHumansInfant, Low Birth WeightInfant, NewbornPregnancyPremature BirthBirth weight discordanceHypertensive disorders of pregnancyOverlap weightingPerinatal outcomesTwin pregnancies

Identifiers

PMID41034731
PMCPMC12486792

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.