ArticleThe Journal of international medical research2025
Nonlinear association between the immunonutritional index hemoglobin, albumin, lymphocytes, and platelets score and hyperuricemia: A cross-sectional study involving 12,598 adults.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nonlinear relationship between erythrocyte distribution width and albumin ratio and prevalence of gout in adult hypertensive patients.Clinical rheumatology · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BackgroundThe prevalence of hyperuricemia is increasing, posing a significant health concern, particularly in China, where it affects 13.3% of the population. Traditional nutritional perspectives do not fully explain hyperuricemia, and the relationship between immune status and hyperuricemia remains unclear.ObjectiveThis study aimed to examine the association between the immunonutritional index-hemoglobin, albumin, lymphocytes, and platelets (HALP) score-and hyperuricemia.MethodsIn this retrospective cross-sectional study, clinical data from 12,598 adults at Guangdong Provincial Hospital of Chinese Medicine were analyzed using SPSS and R.ResultsAmong the total participants, 3422 had hyperuricemia. Significant differences in immune-related indices were observed, with the HALP score showing a higher area under the curve (0.675, 95% confidence interval: 0.665-0.686) than traditional markers. HALP was significantly and nonlinearly associated with hyperuricemia risk, with an inflection point of 53.85. Below this threshold, each unit increase in HALP was associated with a 1.9% increase in risk (p < 0.001).ConclusionThis cross-sectional study identified a nonlinear association between the HALP score and the prevalence of hyperuricemia. These findings suggest that HALP serves as a novel and easily accessible indicator of hyperuricemia, potentially offering insights into its immunometabolic mechanisms for future research. However, further large-scale prospective studies are necessary to confirm this association.
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