ArticleBMC cardiovascular disorders2025
Lymphocyte-to-monocyte ratio is associated with all‑cause and cardiovascular mortality among individuals with diabetes mellitus in the National Health and Nutrition Examination Survey 2003-2018 cohort.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Modulatory Effects of Polyphenols on Altered Leukocyte Functions in Thromboinflammation and Diabetes Mellitus.International journal of molecular sciences · 2026Review
- Correlations of Glycaemic Index and Estimated Whole Blood Viscosity with Blood Cell Indices in Diabetes Mellitus Management: A Clinical Laboratory Medicine Observational Cohort Study.Journal of clinical medicine · 2026Article
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4 authors.
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Abstract
backgroundLimited research has explored the association between the lymphocyte-to-monocyte ratio (LMR) and mortality in patients with diabetes mellitus. We investigated the association of the LMR with both all-cause and cardiovascular mortality in individuals with diabetes mellitus.
methodsThis study enrolled participants from the 2003-2018 National Health and Nutrition Examination Survey (NHANES) cycles. Mortality data were extracted from the National Death Index records. Maximally Selected Rank Statistics (MSRS) was used to identify the best LMR cutoff that was significantly associated with the survival outcomes. Multivariate Cox regression and subgroup analyses were performed to investigate the correlations of the LMR with all-cause and cardiovascular mortality. Restricted cubic splines (RCS) analysis was used to depict the non-linear relationships of the LMR with all-cause and cardiovascular mortality. Time-dependent receiver operating characteristic (ROC) curve analysis was performed to assess the accuracy of the LMR for forecasting the survival outcomes.
resultsOver the median follow-up period of 76 months, 585 of 2,327 participants died, 180 of whom died of cardiovascular mortality. The participants were divided into two groups according to the MSRS: the low LMR (≤ 2.62) and the high LMR (> 2.62) groups. The multivariate Cox regression analysis showed that the high LMR group had a significantly lower risk of all-cause mortality (hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.50-0.76, P < 0.001) and cardiovascular mortality (HR 0.55, 95% CI 0.38-0.81, P = 0.003) than the low LMR group. This trend remained consistent throughout the subgroup analyses, with no significant interaction (P
conclusionIn individuals with diabetes mellitus, high LMR correlated with a reduced risk of all-cause and cardiovascular mortality.
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