ArticleBMC cardiovascular disorders2025
Association between cardiovascular health defined by life's essential 8 and frailty among US adults: a cross-sectional study.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correspondence: Life' s Essential 8 and cardiovascular health: Protective effects on chronic respiratory diseases.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the rapid growth of aging populations, frailty has emerged as a significant global public health concern. However, the relationship between frailty and Life's Essential 8 (LE8), a recently updated measure of cardiovascular health (CVH) introduced by American Heart Association, remains unclear. This study aimed to investigate the association between LE8 and frailty among adult participants. METHOD AND
resultsData from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2018 were analyzed in this study, including adults aged ≥ 20 years. Frailty was assessed using a frailty index (FI), with frailty defined as a FI ≥ 0.21 and moderate/severe frailty defined as FI ≥ 0.30. Multiple Linear, multivariable logistic and restricted cubic spline models were employed to evaluate the associations. A total of 12,707 participants were included. Those in the high-LE8 group exhibited lower FI, frailty prevalence, and moderate/severe frailty prevalence. After adjusting for potential confounders, higher LE8 was significantly associated with lower FI, frailty prevalence, and moderate/severe frailty prevalence. Similar patterns were observed for several components of LE8. Additionally, nonlinear dose-response relationships were identified. Subgroup analyses revealed that the inverse associations between LE8 and FI were consistent across different populations, with stronger associations observed among females, older participants, and those with a lower poverty-income ratio.
conclusionLE8 was inversely associated with the risk of frailty among adult participants. Encouraging the maintenance of optimal cardiovascular health levels may help alleviate the burden of frailty.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.