ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
A comparison of ABR and ASSR using narrow-band-chirp-stimuli in children with single-sided deafness of various etiology.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAuditory steady-state responses (ASSR) are available for frequency-dependent hearing threshold estimation in addition to the technique of conventional auditory brainstem responses (ABR). Although ABR and ASSR principally show strong correlations in hearing threshold estimation, there is preliminary evidence that temporal bone malformations might be associated with significantly greater differences between ABR- and ASSR-results. Therefore, the present study aimed to compare hearing threshold estimation derived from ABR and ASSR in a larger cohort of single-sided deafness (SSD) of various etiology, including temporal bone anomalies.
methodsThe diagnostic consistency between ABR and ASSR using narrow-band-chirp-stimuli at 1000, 2000, and 4000 Hz was analyzed in 47 children with single-sided deafness with varying MRI-morphologic findings: cochlear nerve malformation (CNM, n = 24), cochlear malformation (CM, n = 7) vs. combined malformation (CM + CNM, n = 8) vs. absent temporal bone and inner ear pathology (n = 8). Children with additional health issues other than SSD were excluded.
resultsABR and ASSR showed a strong correlation in deaf ears without malformation (r = 0.728, p < 0.0001), a moderate correlation in isolated cochlear malformation (r = 0.574, p = 0.01), and a weak correlation in case of cochlear nerve anomaly (r = 0.189, p = 0.112 in CNM and r = 0.235, p = 0.268 in CM + CNM). Ears with isolated CNM showed an average discrepancy of 23.40 ± 15.19 dB, p < 0.00001 between ABR and ASSR (vs. 17.08 ± 15.81 dB, p = 0.0008 in CNM + CM, vs. 7.63 ± 8.56 dB, p = 0.008 in CM, vs. 4.38 ± 4.96 dB, p = 0.036 in ears without malformation and vs. 0.36 ± 4.75 dB, p = 0.748 in healthy control ears). In ears with highly discrepant ASSR and ABR values, enlarged ABR wave I and otoacoustic emissions were frequently present.
conclusionIn cochlear nerve malformation, ASSR and ABR frequently provide significantly discrepant hearing threshold estimations, probably derived from a cochlear origin. ASSR should only be used in conjunction with conventional ABR in the diagnostic management of suspected severe-profound hearing loss or deafness in children. A large difference between ASSR and ABR thresholds may indicate a cochlear nerve anomaly.
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