Evidence map›Paper›PMID 41034627›Full record

ArticleCommunications medicine2025

Effects of electroconvulsive therapy on hippocampal longitudinal axis and its association with cognitive side effects.

Olga Therese Ousdal, Miklos Argyelan, Maarten Laroy, Amit Anand, Filip Bouckaert, Joan A Camprodon, Marta Cano, Narcis Cardoner, Udo Dannlowski, Annemiek Dols and 38 more

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Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

48 authors.

Olga Therese OusdalDepartment of Biomedicine, The Faculty of Medicine, University of Bergen, Bergen, Norway. olga.ousdal@uib.no.ORCID http://orcid.org/0000-0002-0728-3141
Miklos ArgyelanFeinstein Institutes for Medical Research, Institute of Behavioral Science, Manhasset, NY, USA.ORCID http://orcid.org/0000-0002-7254-1776
Maarten LaroyKU Leuven, Leuven Brain Institute, Department of Neurosciences, Neuropsychiatry, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3673-122X
Amit AnandHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1016-6904
Filip BouckaertGeriatric Psychiatry, University Psychiatric Center KU Leuven, Leuven, Belgium.
Joan A CamprodonDivision of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1282-9257
Marta CanoDivision of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0675-9483
Narcis CardonerSant Pau Mental Health Research Group, Institut d'Investigació Biomédica Sant Pau, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9633-0888
Udo DannlowskiInstitute for Translational Psychiatry, University of Muenster, Muenster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
Annemiek DolsAmsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Neuroscience, Amsterdam, The Netherlands.
Louise EmsellKU Leuven, Leuven Brain Institute, Department of Neurosciences, Neuropsychiatry, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0011-4158
Randall EspinozaDepartments of Neurology and Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2895-4212
Kaat HebbrechtUniversity Psychiatric Center KU Leuven, Department of Psychiatry, Leuven, Belgium.
René HurlemannDepartment of Psychiatry and Psychotherapy, School of Medicine & Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.ORCID http://orcid.org/0000-0003-2628-565X
Martin JorgensenPsychiatric Center Copenhagen and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1321-8901
Maximilian KiebsDepartment of Psychiatry and Psychotherapy, School of Medicine & Health Sciences, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Taishiro KishimotoHills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio University School of Medicine, Tokyo, Japan.
Katherine L NarrDepartments of Neurology and Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9396-7936
Pia NordanskogCenter for Social and Affective Neuroscience (CSAN), Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Nils OpelDepartment of Psychiatry, University of Jena, Jena, Germany.
Ronny RedlichInstitute of Translational Psychiatry, University of Muenster, Muenster, Germany.
Didi RhebergenAmsterdam Public Health Research Institute, Department of Mental Health, Amsterdam UMC, Amsterdam, The Netherlands.
Alexander SartoriusDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1243-3693
Didier SchrijversCollaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerpen, Belgium.
Pascal SienaertAcademic Center for ECT and Neuromodulation (AcCENT) University Psychiatric Center, KU Leuven, Kortenberg, Belgium.ORCID http://orcid.org/0000-0002-0650-415X
Carles Soriano-MasCIBERSAM, Carlos III Health Institute, Madrid, Spain.
Akihiro TakamiyaHills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2985-6673
Freek Ten DoesschateDepartment of Psychiatry, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.
Indira TendolkarDonders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Radboud University Nijmegen, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-3171-3671
Mikel UrretavizcayaCIBERSAM, Carlos III Health Institute, Madrid, Spain.
Linda van DiermenCollaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerpen, Belgium.ORCID http://orcid.org/0000-0002-3178-4974
Philip van EijndhovenDonders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Radboud University Nijmegen, Nijmegen, The Netherlands.
Guido van WingenAmsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3076-5891
Jeroen van WaardeDepartment of Psychiatry, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.ORCID http://orcid.org/0000-0001-6792-5727
Mathieu VandenbulckeKU Leuven, Leuven Brain Institute, Department of Neurosciences, Neuropsychiatry, Leuven, Belgium.
Joey VerdijkDepartment of Psychiatry, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.
Benjamin S C WadeDivision of Neuropsychiatry and Neuromodulation, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2461-6101
Yrondi AntoineService de Psychiatrie et Psychologie Médicale, Centre Expert Dépression Résistante, Foundation Fondamental, CHU, Toulouse, France.
Njål BrekkeMohn Medical Imaging and Visualization Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Joan PrudicDepartment of Psychiatry, Colombia School of Medicine, New York, NY, USA.
Shawn McClintockDivision of Psychology, Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
Ute KesslerDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Hauke BartschMohn Medical Imaging and Visualization Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway.ORCID http://orcid.org/0000-0003-1486-4128
Ketil OdegaardDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Jan HaavikDepartment of Biomedicine, The Faculty of Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-7865-2808
Åsa HammarDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Christopher AbbottDepartment of Psychiatry, University of New Mexico, Albuquerque, NM, USA.ORCID http://orcid.org/0000-0001-6884-2464
Leif OltedalMohn Medical Imaging and Visualization Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway.ORCID http://orcid.org/0000-0003-3316-7950

Funding

1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128690 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Katherine L Narr · 2022 to 2026
$2.9M
2/4 Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128692 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher C Abbott · 2022 to 2026
$2.6M
Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depressionR33MH125126 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2023 to 2025
$2.0M
ECT current amplitude and medial temporal lobe engagementU01MH111826 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2017 to 2019
$1.5M
Neural Biomarkers of ECT Response in SchizophreniaK23MH120504 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI ARGYELAN, MIKLOS · 2020 to 2023
$781k
ECT current amplitude and medial temporal lobe engagementR01MH111826 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2016 to 2016
$522k
Electrical Field and Neuroimaging Based Prediction of ECT Induced Clinical and Cognitive EffectsR21MH119616 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI ARGYELAN, MIKLOS · 2019 to 2020
$454k
Helse Vest (Western Norway Regional Health Authority) 912275NIMH NIH HHS K23 MH120504NIMH NIH HHS R01 MH111826NIMH NIH HHS R01 MH128690NIMH NIH HHS R01 MH128692NIMH NIH HHS R21 MH119616NIMH NIH HHS R33 MH125126NIMH NIH HHS U01 MH111826
6 · The paper itself

Abstract

backgroundElectroconvulsive therapy (ECT)-mediated hippocampal volumetric increase is consistently reported, though its clinical relevance remains debated. This study evaluates if ECT-related cognitive side effects are associated with regional volumetric changes along the hippocampal longitudinal axis.

methodsLongitudinal T1-weighted MRI scans in 435 patients (54.0 ± 15.0 years, 261 female) with major depression from the Global ECT-MRI Research Collaboration (GEMRIC) were used to measure changes in right global and longitudinal axis hippocampal subdivisions (head, body, tail) from baseline to post-treatment. Cognitive side effects were evaluated using pre-to-post treatment changes in two different verbal fluency tests available for 124 patients. Electric field modelling was applied to explore whether the regional hippocampal electric field strength related to individual changes in cognitive performance.

resultsGlobal hippocampal enlargement is observed pre-to-post ECT (p

conclusionsThe findings support that cognitive performance following ECT relates to macrostructural changes in the posterior cognitive hippocampus. Thus, there may be a threshold of ECT induced posterior hippocampal volumetric change, beyond which cognitive side effects occur.

Identifiers

PMID41034627
PMCPMC12489027

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