ArticleCell research2025
Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating.
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Article in Cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
–field-weighted citation impact
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Who cites it
9 citing papers in PubMed.
- Structural and kinetic mechanisms of state-dependent potassium channel inhibition.Science advances · 2026Article
- Article
- The SIMDA framework maps PIP2-binding sites regulating the KCNQ1 channel.Nature communications · 2026Article
- Cannabidiol inhibits both human KActa pharmacologica Sinica · 2026Article
- Structural basis of the neuronal M-current generated by an asymmetric KCNQ2/3 assembly.Cell research · 2026Article
- PIPNature communications · 2026Article
- A mechanistic understanding of how KCNE1 tunes KCNQ1 channel pharmacology.Structure (London, England : 1993) · 2026Article
- High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants.JCI insight · 2026Article
- KCNQ1 and PIPCell research · 2025Article
Corrections and comments
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Authors and funding
30 authors.
Ling Zhong *Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.ORCID 0009-0005-2191-2521
Xiaoqing Lin *Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.ORCID 0009-0008-0261-9794
Xinyu Cheng *The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0009-0007-3641-8336
Shuangyan Wan *The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Yaoguang HuaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Weiwei NanThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Bin HuSchool of Basic Medical Sciences, Gannan Medical University, Ganzhou, Jiangxi, China.
Xiangjun PengDepartment of Engineering Mechanics, Applied Mechanics Laboratory, Institute of Biomechanics and Medical Engineering, Tsinghua University, Beijing, China.ORCID 0009-0006-0434-526X
Zihan ZhouShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Qiansen ZhangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.ORCID 0000-0002-8608-3067
Huaiyu YangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.ORCID 0000-0003-2358-1840
Frank NoéDepartment of Mathematics and Informatics, Freie Universität Berlin, Berlin, Germany.
Zhenzhen YanDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Dexiang JiangDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Hangyu ZhangDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Fengjiao LiuDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Chenxin XiaoDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Zhuo ZhouDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Yimin MouDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Haijie YuDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.ORCID 0000-0003-4059-1282
Lijuan MaDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Chen HuangDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Vincent Kam Wai WongDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Sookja Kim ChungDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Bing ShenDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Zhi-Hong JiangDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.ORCID 0000-0002-7956-2481
Erwin NeherDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China.
Wandi ZhuCollege of Medicine, Department of Molecular Medicine and Therapeutics, The Ohio State University. Columbus, OH, USA.ORCID 0000-0003-0927-5687
Jin ZhangThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. zhangxiaokong@hotmail.com.ORCID 0000-0002-9705-0033
Panpan HouDr. Neher's Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine & School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China. pphou@must.edu.mo.ORCID 0000-0001-7694-2262
Funding
Macau University of Science and Technology Foundation (MUST Foundation) FRG-23-030-SKLNational Natural Science Foundation of China (National Science Foundation of China) 32171221National Natural Science Foundation of China (National Science Foundation of China) 32271260
Abstract
The KCNQ1 + KCNE1 potassium channel complex produces the slow delayed rectifier current (I
Indexed as
Ion Channel GatingKCNQ1 Potassium ChannelPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Voltage-GatedAnimalsCryoelectron MicroscopyHumansProtein BindingProtein Structure, SecondaryKCNE1 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Voltage-Gated
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.