Evidence map›Paper›PMID 41034585›Full record

ArticleNature2025

Dietary cysteine enhances intestinal stemness via CD8

Fangtao Chi, Qiming Zhang, Jessica E S Shay, Shixun Han, Johanna Ten Hoeve, Yin Yuan, Zhenning Yang, Heaji Shin, Samuel Block, Sumeet Solanki and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Fangtao ChiDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Qiming ZhangDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0003-4282-2996
Jessica E S ShayDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0001-7799-1349
Shixun HanDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Johanna Ten HoeveUCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Yin YuanDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0003-0078-8769
Zhenning YangDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Heaji ShinDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0001-5208-5999
Samuel BlockDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.
Sumeet SolankiMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.
Yatrik M ShahMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2487-4816
Matthew G Vander HeidenDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA.ORCID 0000-0002-6702-4192
Judith AgudoDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-3576-3169
Ömer H YilmazDepartment of Biology, The David H. Koch Institute for Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA. ohyilmaz@mit.edu.ORCID 0000-0002-7577-4612

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.R01CA257523 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, STAPPENBECK, THADDEUS S · 2021 to 2025
$3.7M
Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunctionR01DK126545 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLOVERPRIS, HENRIK, KWON, DOUGLAS · 2020 to 2024
$3.6M
Immunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH)R01DK133919 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Douglas Kwon, Omer Yilmaz · 2022 to 2026
$3.5M
Developing high-throughput genetic perturbation strategies for single cells in cancer organoidsU01CA250554 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE, YILMAZ, OMER · 2020 to 2022
$2.8M
The lysosomal fasting response in intestinal stem cells and cancerR01DK140310 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2024 to 2026
$2.4M
Impact of fasting on intestinal stem cells and cancerR01CA245314 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Omer Yilmaz · 2020 to 2026
$2.3M
Dietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0M
NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA211184NCI NIH HHS R01 CA245314NCI NIH HHS R01 CA257523NCI NIH HHS U01 CA250554NIDDK NIH HHS R01 DK126545NIDDK NIH HHS R01 DK133919NIDDK NIH HHS R01 DK140310
6 · The paper itself

Abstract

A fundamental question in physiology is understanding how tissues adapt and alter their cellular composition in response to dietary cues

Indexed as

CD8-Positive T-LymphocytesCysteineInterleukin-22IntestinesStem CellsAnimalsDietFemaleIntestinal MucosaMaleMiceMice, Inbred C57BLRegenerationSignal TransductionCysteineInterleukin-22

Identifiers

PMID41034585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.