ArticleNature2025
Proteotoxic stress response drives T cell exhaustion and immune evasion.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
–field-weighted citation impact
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Who cites it
42 citing papers in PubMed.
- Article
- Impact of Chronic Stress and Trauma on Asthma Pathophysiology and Outcomes.Current allergy and asthma reports · 2026Review
- Microfluidic-based rapid generation of chimeric antigen receptor T cells improves low-multiplicity-of-infection transduction efficiency while preserving functional activity.Journal of translational medicine · 2026Article
- Sex-specific trajectories of nonlinear immune aging at single-cell level.Nature communications · 2026Article
- Therapeutic vaccines targeting solid tumors: A series of clinical trial analysis over the past decade.Translational oncology · 2026Review
- Article
- Implications of Rho GTPase signaling in cancer immunotherapy.Biochemical Society transactions · 2026Review
- Integrated Single-Cell and TCR Profiling Reveals Protection-Associated CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Extracellular Vesicles as Master Regulators of Immune Modulation in Multiple Myeloma.International journal of molecular sciences · 2026Review
- Immunometabolic Stress and Immune Suppression in Clear-Cell Renal Cell Carcinoma: Perspectives in Therapeutic Strategy.International journal of molecular sciences · 2026Review
- Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning.BMC cancer · 2026Article
- Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity.Cancer research · 2026Article
- Single-cell gain-of-function mapping reveals latent regulatory programs governing CD8Research square · 2026Article
- Regulatory heme: a mitochondria-to-nucleus messenger of CD8Cellular & molecular immunology · 2026Article
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Exploratory multiomics analysis identifies WDR17 as a potential biomarker of tyrosine kinase inhibitor resistance in lung adenocarcinoma.Discover oncology · 2026Article
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.Cell · 2026Article
- Hypoxia Impairs CD8Cancers · 2026Article
Corrections and comments
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Authors and funding
25 authors.
Yi WangPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0000-0002-4046-9511
Anjun MaPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0000-0001-6269-398X
No-Joon SongPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.
Ariana E ShannonPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0000-0002-5563-8824
Yaa S AmankwahPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.
Xingyu ChenJohns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9284-4950
Weidong WuDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.ORCID 0009-0003-7500-1163
Ziyu WangPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0009-0006-0763-3259
Abbey A SaadeyDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, USA.
Amir YousifDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, USA.
Gautam GhoshDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Jay K MandulaPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.
Maria VelegrakiPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.
Tong XiaoPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.
Haitao WenPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0000-0002-6363-2748
Stanley Ching-Cheng HuangDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-6557-3737
Ruoning WangCenter for Childhood Cancer, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-9798-8032
Christian M BeuschDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
Abdelhameed S DawoodDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
David E GordonDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0001-7954-0306
Mohamed S Abdel-HakeemDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0003-0226-3464
Hazem E GhoneimPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0000-0002-9816-4286
Gang XinPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.
Brian C SearlePelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA.ORCID 0000-0001-8760-6731
Zihai LiPelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center-The James, Columbus, OH, USA. Zihai.li@osumc.edu.ORCID 0000-0003-4603-927X
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3MThe Role of the Y Chromosome in Bladder Tumor Development, Growth And ProgressionP01CA278732 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Hany Abdel-Malek Abdel-Hafiz · 2023 to 2026
$10.7MMetabolic programming in TH17 cell differentiationR01AI114581 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WANG, RUONING · 2015 to 2025
$3.6MTargeting GARP-TGFbeta for Immunotherapy of Non-Small Cell Lung CancerR01CA282501 · NCI · OHIO STATE UNIVERSITY · PI Zihai Li · 2024 to 2026
$3.1MTargeting GRP94-TGF-beta Pathway for Cancer Immunotherapy SupplementR01CA262069 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2021 to 2025
$2.9MEnhancing the Effectiveness of Immunotherapies by T Cell Epigenetic ReprogrammingR01AI170926 · NIAID · OHIO STATE UNIVERSITY · PI Hazem E. Ghoneim · 2023 to 2026
$2.6MModulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapyR01CA247941 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WANG, RUONING · 2021 to 2025
$2.4MInvestigating the functional impact of genetic variants in the human proteomeR35GM150723 · NIGMS · OHIO STATE UNIVERSITY · PI Brian Chih-Seng Searle · 2023 to 2026
$1.6MUsing proteogenomics to assess the functional impact of alternative splicing events in glioblastomaR21CA267394 · NCI · SWEDISH MEDICAL CENTER, FIRST HILL · PI COBBS, CHARLES S, SEARLE, BRIAN CHIH-SENG · 2023 to 2024
$426kNCI NIH HHS P01 CA278732NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA247941NCI NIH HHS R01 CA262069NCI NIH HHS R01 CA282501NCI NIH HHS R21 CA267394NIAID NIH HHS R01 AI114581NIAID NIH HHS R01 AI170926NIGMS NIH HHS R35 GM150723
Abstract
Chronic infections and cancer cause T cell dysfunction known as exhaustion. This cell state is caused by persistent antigen exposure, suboptimal co-stimulation and a plethora of hostile factors that dampen protective immunity and limit the efficacy of immunotherapies
Indexed as
CD8-Positive T-LymphocytesProteotoxic StressStress, PhysiologicalT-Cell ExhaustionAnimalsAutophagyFemaleHumansImmune EvasionMaleMiceMice, Inbred C57BLProtein BiosynthesisProteomeProteostasisRNA, MessengerProteomeRNA, Messenger
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.