ArticleNature2025
The Panoptes system uses decoy cyclic nucleotides to defend against phage.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026Review
- Turning a phage anti-defense weapon into an immunity trigger.PLoS biology · 2026Article
- Convergent evolution of viral nucleases targeting cyclic dinucleotides.PLoS pathogens · 2026Review
- Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems.PLoS biology · 2026Article
- Recent Advances in the Molecular Mechanisms of Bacterial Anti-Phage Defence Systems.Microbial biotechnology · 2026Article
- Review
- Balancing of immune activation and suppression during phage infection.bioRxiv : the preprint server for biology · 2026Article
- Functional diversity of phage sponge proteins that sequester host immune signals.Nature microbiology · 2026Article
- The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence.The Biochemical journal · 2026Article
- A phage-encoded sponge protein suppresses bacterial TIR-Caspase immune signaling.Nature communications · 2026Article
- Bacterial 2',3'-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication.Cell host & microbe · 2026Article
- Article
- Divergent viral phosphodiesterases for immune signaling evasion.Cell host & microbe · 2025Article
Corrections and comments
- Update of
Authors and funding
19 authors.
Ashley E SullivanDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0003-4984-328X
Ali NabhaniDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0001-7103-8573
Daniel S IzrailevskyDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0009-0000-1148-4539
Kate SchinkelDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Charlotte R K HoffmanDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.ORCID 0009-0006-0766-5509
Laurel K RobbinsDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Toni A NagyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Melissa L DuncanDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Hannah E LedvinaDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Annette H ErbseDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Emily M KibbyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Uday TakDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
David M DinhDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Eirene Marie Q EdnacotDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
Christy M NguyenDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-3897-6207
A Maxwell BurroughsComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2229-8771
L AravindComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0771-253X
Aaron T WhiteleyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA. aaron.whiteley@colorado.edu.ORCID 0000-0002-0075-7519
Benjamin R MorehouseDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA. b.morehouse@uci.edu.ORCID 0000-0003-3352-5463
Funding
A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS · 2017 to 2026
$28.6MEvolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZIALM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ARAVIND, L · 2009 to 2025
$20.3MTRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9MPredoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6MInterdisciplinary Predoctoral Training in Molecular BiophysicsT32GM145437 · NIGMS · UNIVERSITY OF COLORADO · PI JOSEPH J FALKE · 2022 to 2026
$2.5MResearch Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)DP2AT012346 · NCCIH · UNIVERSITY OF COLORADO · PI WHITELEY, AARON THOMAS · 2022 to 2025
$2.4MDefining the mechanisms that drive novel cyclic nucleotide signaling in immune defenseR35GM157311 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Benjamin Robert Morehouse · 2025 to 2026
$760kModernization/operational improvements to basic centrifugation infrastructure of the Shared Instruments Pool in the Department of Biochemistry University of Colorado BoulderR24OD033699 · OD · UNIVERSITY OF COLORADO · PI ERBSE, ANNETTE H · 2022 to 2022
$143kPurchase of an Isothermal Titration CalorimeterS10RR026516 · NCRR · UNIVERSITY OF COLORADO · PI BATEY, ROBERT T · 2010 to 2010
$129kUnderstanding the role of ubiquitination-like processes in bacterial antiviral immunityF31AI186492 · NIAID · UNIVERSITY OF COLORADO · PI Ashley Elizabeth Sullivan · 2025 to 2026
$86kIntramural NIH HHS ZIA LM594244NCCIH NIH HHS DP2 AT012346NCRR NIH HHS S10 RR026516NIAID NIH HHS F31 AI186492NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM157311NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607NIGMS NIH HHS T32 GM145437NIH HHS R24 OD033699
Abstract
Bacteria combat phage infection using antiphage systems and many systems generate nucleotide-derived second messengers upon infection that activate effector proteins to mediate immunity
Indexed as
BacteriophagesNucleotides, CyclicOperonSecond Messenger SystemsCRISPR-Cas SystemsCrystallography, X-RayDinucleoside PhosphatesModels, MolecularProtein DomainsViral Proteinscyclic diadenosine phosphateDinucleoside PhosphatesNucleotides, CyclicViral Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.