ArticleNature2025
A miniature CRISPR-Cas10 enzyme confers immunity by inhibitory signalling.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026Review
- Immune safeguarding as a conserved principle of antiviral defence.Nature reviews. Microbiology · 2026Article
- Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems.PLoS biology · 2026Article
- Turning a phage anti-defense weapon into an immunity trigger.PLoS biology · 2026Article
- Recent Advances in the Molecular Mechanisms of Bacterial Anti-Phage Defence Systems.Microbial biotechnology · 2026Article
- Review
- A Noncontiguous Code for RNA-Guided DNA Recognition Preceded CRISPR.bioRxiv : the preprint server for biology · 2026Article
- Balancing of immune activation and suppression during phage infection.bioRxiv : the preprint server for biology · 2026Article
- Functional diversity of phage sponge proteins that sequester host immune signals.Nature microbiology · 2026Article
- The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence.The Biochemical journal · 2026Article
- A phage-encoded sponge protein suppresses bacterial TIR-Caspase immune signaling.Nature communications · 2026Article
- Bacterial 2',3'-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication.Cell host & microbe · 2026Article
- Article
- Divergent viral phosphodiesterases for immune signaling evasion.Cell host & microbe · 2025Article
- Article
- Viral effectors trigger innate immunity across the tree of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
Corrections and comments
- Update of
Authors and funding
13 authors.
Erin E Doherty *Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-1555-4124
Benjamin A Adler *Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-7488-3040
Peter H YoonInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Kendall HsiehDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Kenneth LoiDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Emily G ArmbrusterSchool of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-0377-1209
Arushi LahiriDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Cydni S BollingInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Xander E WilcoxDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY, USA.
Amogha AkkatiDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Anthony T IavaroneCalifornia Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.
Joe PoglianoSchool of Biological Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8989-2655
Jennifer A DoudnaInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. doudna@berkeley.edu.ORCID 0000-0001-9161-999X
Funding
Targeting Viroporins and Coronavirus M ProteinU19AI171110 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$103.4MA Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3MProject 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$35.7MRESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Melanie Maria Ott · 2018 to 2026
$21.4MResource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIREN MURTHY · 2023 to 2026
$19.7MPathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9MMolecular and cellular biology of the phage nucleus and spindleR01GM129245 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POGLIANO, JOSEPH A · 2018 to 2025
$4.2MExpanding CRISPR-Cas editing technology through exploration of novel Cas proteins and DNA repair systemsU01AI142817 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BANFIELD, JILLIAN, DOUDNA, JENNIFER A · 2018 to 2022
$2.0MHost-Microbe Interactions that Determine Host Traits and DiseaseT32AI145821 · NIAID · CORNELL UNIVERSITY · PI LAZZARO, BRIAN · 2020 to 2024
$1.9MCas9 RNP delivery to immune cells in vivo via molecular targetingUH3AI150552 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI DOUDNA, JENNIFER A, WILSON, ROSS C · 2022 to 2022
$1.3MHigh Definition Ion Mobility SpectrometerS10OD020062 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI WILLIAMS, EVAN R · 2015 to 2015
$590kTargeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery VehiclesR21HL173710 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI DOUDNA, JENNIFER A · 2024 to 2025
$520kHoward Hughes Medical InstituteNHLBI NIH HHS R21 HL173710NIAID NIH HHS T32 AI145821NIAID NIH HHS U01 AI142817NIAID NIH HHS U19 AI135990NIAID NIH HHS U19 AI171110NIAID NIH HHS U54 AI170792NIAID NIH HHS UH3 AI150552NIGMS NIH HHS F32 GM153031NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM129245NIGMS NIH HHS T32 GM133351NIH HHS S10 OD020062NINDS NIH HHS U19 NS132303
Abstract
Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signalling that share mechanistic features with human antiviral systems
Indexed as
CRISPR-Cas SystemsOligonucleotidesSignal TransductionAdenylyl CyclasesCell DeathDinucleoside PhosphatesHEK293 CellsHumansImmune EvasionMembrane ProteinsModels, MolecularSTING ProteinAdenylyl Cyclasescyclic diadenosine phosphateDinucleoside PhosphatesMembrane ProteinsOligonucleotidesSTING1 protein, humanSTING Protein
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.