ArticleMikrochimica acta2025
Proof-of-concept study of a CD-type microfluidic titration system with an ISFET sensor for microlitre-scale analysis.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Portable microfluidic titration using a cross-shaped microfluidic device and smartphone camera for on-site quantitative analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Conventional titration methods rely on bulky equipment, large sample volumes, and manual reagent handling, limiting their integration into portable and microlitre-scale analytical platforms. This constraint persists despite the growing demand for compact chemical quantification tools in decentralized diagnostics and environmental monitoring. A key challenge remains the lack of precise, automated titration systems that can operate without external pumps, fragile electrodes, or complex tubing. To address this gap, we present a CD-type centrifugal microfluidic device integrated with an ion-sensitive field-effect transistor (ISFET) sensor for automated acid-base titration in microlitre-scale samples. Rotation-driven fluid control is employed in the lab-on-a-disc system, enabling sequential acid addition without external pumps or valves. The 3D-printed microfluidic chip incorporates ten reagent reservoirs connected to an outer reaction chamber, allowing precise titrant delivery through controlled rotational speeds. The ISFET sensor, featuring a Ta₂O₅ sensing membrane and a carbon-based reference electrode, exhibited high sensitivity (51.3 mV/pH) and notable linearity (R
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