ArticleScientific reports2025
Uniform intrahepatic portal ammonia distribution in cirrhosis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Revisiting gut microbiota-driven ammonia metabolism: from disease burden to physiological adaptation.Gut microbes · 2026Review
- Beyond "left or right": future implications for study design and endpoints in TIPS portal branch selection.Hepatology international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower rates of hepatic encephalopathy (HE) following left-sided transjugular intrahepatic portosystemic shunt (TIPS) placement have been hypothesized to stem from a distinct ammonia distribution within the portal venous system. This prospective study investigated ammonia concentrations at five portal and splanchnic venous sites in 50 fasting cirrhotic patients (20 female [40%]; mean age: 60.4 years) prior to TIPS implantation for ascites (33/50, 66%) or variceal bleeding (17/50, 34%). While ammonia levels were significantly higher in the superior mesenteric vein (mean: 143 µg/dl) compared to the splenic vein (mean: 66 µg/dl; p < 0.001), mean ammonia concentrations in the right (104 µg/dl) and left (107 µg/dl) portal vein branches were found to be equivalent (p = 0.008 for equivalence). No systematic differences between right and left portal vein ammonia were observed. These findings suggest that in fasting cirrhotic patients, local ammonia levels in the main portal vein branches do not differ significantly. Therefore, other factors likely contribute to any observed differences in HE rates related to TIPS placement site, warranting further investigation into alternative mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.