Evidence map›Paper›PMID 41034496›Full record

ArticleNature biotechnology2025

Scaling DNA synthesis with a microchip-based massively parallel synthesis system.

Xiandi Zhang, Xiang'er Jiang, Yun Wang, Qinzhen Chen, Hao Jiang, Hu Zhang, Antoni Beltran, Weiya Yang, Tai Chen, Chenglong Liang and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Xiandi Zhang *BGI Research, Changzhou, China.
Xiang'er Jiang *BGI Research, Changzhou, China.
Yun WangBGI Research, Changzhou, China.
Qinzhen ChenBGI Research, Changzhou, China.
Hao JiangBGI Research, Changzhou, China.
Hu ZhangBGI Research, Changzhou, China.
Antoni BeltranCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Weiya YangBGI Research, Changzhou, China.
Tai ChenGCATbio, Changzhou, China.
Chenglong LiangBGI Research, Changzhou, China.
Ning ChengBGI Research, Changzhou, China.
Yun HuangBGI Research, Changzhou, China.
Guqiao DingState Key Laboratory of Materials for Integrated Circuits, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, China.
Chengwang XieBGI Research, Changzhou, China.
Nanfeng GaoBGI Research, Changzhou, China.
Juntao LiuMGI Tech, Qingdao, China.
Wei XuMGI Tech, Qingdao, China.
Jinlei HuangMGI Tech, Qingdao, China.
Dong CaiGuangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.
Lihao ZhuGuangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.
Songjin MoGuangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.
Mengzhe ShenGuangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.
Wenwei ZhangGuangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0001-9220-2467
Ben LehnerCentre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Ming NiMGI Tech, Qingdao, China.
Jian WangBGI, Shenzhen, China.
Xun XuGuangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0002-5338-5173
Yue ShenBGI Research, Changzhou, China. shenyue@genomics.cn.ORCID http://orcid.org/0000-0002-3276-7295

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32322047National Natural Science Foundation of China (National Science Foundation of China) 32401214
6 · The paper itself

Abstract

Current high-throughput DNA synthesis technologies use intricate chip and microfluidic systems to produce large-scale synthetic oligonucleotides but with low concentration and limited compatibility for long DNA assembly. Here we report a massive-in-parallel synthesis system, with an 'identification-sorting-synthesis-recycling' iteration mechanism applied to microchips for high-throughput DNA synthesis. This approach increases DNA product concentration by four to six orders of magnitude and simplifies downstream processes for large-scale gene synthesis.

Identifiers

PMID41034496

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.