ArticleCommunications biology2025
Photosensitizer-specific bacterial stress responses in Escherichia coli reveal distinct targets in photoinduced inactivation.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Traditional plant urologicals curb early uropathogenic E. coli infection and strengthen host innate defense.Applied microbiology and biotechnology · 2026Article
- Beyond Resistance: Phenotypic Plasticity in Bacterial Responses to Antibiotics, Oxidative Stress and Antimicrobial Photodynamic Inactivation.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The ongoing antibiotic crisis calls for alternative antimicrobial strategies. Antimicrobial photodynamic therapy (aPDT) offers a sustainable option, employing a light-activated photosensitizer (PS) to generate cytotoxic reactive oxygen species (ROS). The non-selective nature of these ROS helps minimize the risk of resistance development. Despite the development of numerous PSs, limited data on their exact mechanisms and bacterial targets still hinders broader clinical use. The focus of this study is to address this gap by capturing pathway-specific responses to sub-lethal photodynamic stress using a panel of transcriptional biosensors in E. coli K-12 strain MG1655. Our results indicate that methylene blue (MB) primarily causes oxidative stress in the cytosol while silicon phthalocyanine derivative (SiPc) induces envelope stress at physiological conditions. By monitoring well-characterized stress response pathways, our method offers a valuable tool for elucidating the physiological effects of aPDT and guiding more detailed mechanistic or transcriptomic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.