Evidence map›Paper›PMID 41034442›Full record

ArticleScientific reports2025

Reduction in Asymptomatic falciparum malaria infection amongst schoolchildren in three ecological zones of Ghana between 2017 and 2023.

Raphael Lartey Abban, Lucas Amenga-Etego, Abena Busayomi, Festus Kojo Acquah, Gabriel Bright Dzotefe, Victor Edem Kornu, Kwadwo Asamoah Kusi, Linda Eva Amoah, Yaw Asare Afrane

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raphael Lartey AbbanCenter for Vector-Borne Disease Research, Department of Medical Microbiology, College of Health Sciences, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Lucas Amenga-EtegoDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Abena BusayomiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Festus Kojo AcquahDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Gabriel Bright DzotefeCenter for Vector-Borne Disease Research, Department of Medical Microbiology, College of Health Sciences, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Victor Edem KornuWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Accra, Ghana.
Kwadwo Asamoah KusiDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
Linda Eva AmoahDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana. lamoah@noguchi.ug.edu.gh.
Yaw Asare AfraneCenter for Vector-Borne Disease Research, Department of Medical Microbiology, College of Health Sciences, University of Ghana Medical School, University of Ghana, Accra, Ghana.

Funding

Regional Centre for Vector Borne Diseases in West Africa (RCVBD)D43TW011513 · FIC · UNIVERSITY OF GHANA · PI YAW ASARE AFRANE, Guiyun Yan · 2021 to 2026
$1.5M
FIC NIH HHS D43 TW011513National Institute of Health (NIH) (D43 TW011513)WACCBIP-World Bank ACE PhD fellowship (WACCBIP+NCDs: Awandare)
6 · The paper itself

Abstract

Despite the implementation of intervention measures, eliminating malaria in Ghana remains challenging due to the presence of a significant number of asymptomatic malaria-infected individuals. This study aimed to determine the temporal dynamics and spatial distribution of asymptomatic malaria amongst schoolchildren, by comparing infection from a cross-sectional study conducted in 2023 with a previously published data in 2017 in the same sites in Ghana. Schoolchildren were screened using microscopy and PCR for malaria infection during the dry and rainy seasons in 2023 (1,154 participants) and compared with data from 2017 (1,109 participants). Asymptomatic P. falciparum infection by microscopy decreased from 16.05 in 2017 to 1.21% in 2023, and by PCR from 39.95% in 2017 to 17.33% in 2023. Infection rates in the Sahel zone decreased significantly by 60% in 2023 compared to 2017. Submicroscopic infections were higher in 2017 (24.35%) than 2023 (16.46%), with the forest zone having the highest submicroscopic infections at both timepoints 2017 (47.01%) and 2023 (28.28%). Asymptomatic malaria infections in the schoolchildren decreased between 2017 and 2023. Continuous surveillance and improved interventions are needed to further reduce the parasite carriage, especially among schoolchildren.

Indexed as

Asymptomatic InfectionsMalaria, FalciparumPlasmodium falciparumAdolescentChildCross-Sectional StudiesFemaleGhanaHumansMaleMicroscopyPrevalenceSeasonsEcological zonesGhanaPlasmodiumSchoolchildrenSubmicroscopic infections

Identifiers

PMID41034442
PMCPMC12488871

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.