Evidence map›Paper›PMID 41034378›Full record

ArticleCommunications biology2025

Intermittent fasting attenuates glial hyperactivation and photoreceptor degeneration in a NaIO

Jingzhen Li, Beibei Wang, Pinjie Liu, Xuecheng Qiu, Qiyun Bian, Congxin Shen, Yanyan Li, Mengwen Shao, Meng Li

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingzhen Li *Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.ORCID http://orcid.org/0000-0003-2974-6677
Beibei Wang *Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Pinjie LiuJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Xuecheng QiuJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Qiyun BianJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Congxin ShenJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Yanyan LiJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Mengwen ShaoJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Meng LiJiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China. limeng@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-0145-5440

Funding

Jiangsu Provincial Department of Education (Department of Education Jiangsu Province) 24KJA310011National Natural Science Foundation of China (National Science Foundation of China) 32100769National Natural Science Foundation of China (National Science Foundation of China) 82371401
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss, with limited treatments available. Recent studies suggest intermittent fasting (IF) may offer neuroprotective benefits for aging and age-related disorders, but its efficacy in AMD has not yet been established. Here, using a sodium iodate (NaIO

Indexed as

FastingMacular DegenerationNeurogliaPhotoreceptor Cells, VertebrateAnimalsDisease Models, AnimalIntermittent FastingIodatesMaleMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesRetinal Pigment EpitheliumIodatesReactive Oxygen Speciessodium iodate

Identifiers

PMID41034378
PMCPMC12488855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.