Evidence map›Paper›PMID 41034252›Full record

ArticleScientific reports2025

Structural and molecular differentiation of cultured human neurons is accompanied by alterations of spontaneous and evoked calcium dynamics.

Deepika Negi, Susan Shorter, Iain Goodhall, Daniel Razansky, Sukhi Shergill, Saak V Ovsepian

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Deepika NegiFaculty of Engineering and Science, University of Greenwich London, Chatham Maritime, London, ME4 4TB, UK.
Susan ShorterFaculty of Engineering and Science, University of Greenwich London, Chatham Maritime, London, ME4 4TB, UK.
Iain GoodhallFaculty of Engineering and Science, University of Greenwich London, Chatham Maritime, London, ME4 4TB, UK.
Daniel RazanskyFaculty of Medicine, Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland. daniel.razansky@uzh.ch.
Sukhi ShergillDepartment of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Saak V OvsepianFaculty of Engineering and Science, University of Greenwich London, Chatham Maritime, London, ME4 4TB, UK. s.v.ovsepian@gre.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During development, neuronal precursors transform from a pluripotent state into specialized neurons. While much research has been conducted into morphological and molecular changes, there is a pressing need to define accompanying functional alterations. We used immunofluorescence microscopy and live imaging in SH-SY5Y-derived human neurons to elucidate the relationship between structural and molecular differentiation with evoked and spontaneous Ca

Indexed as

CalciumCalcium SignalingCell DifferentiationNeuronsBrain-Derived Neurotrophic FactorCell Line, TumorCells, CulturedHumansTretinoinBrain-Derived Neurotrophic FactorCalciumTretinoinBDNFCalcium imagingMolecular polarizationNeuroblastoma-derived neuronsSH-SY5Y cellsSpontaneous activity

Identifiers

PMID41034252
PMCPMC12489043

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.