Evidence map›Paper›PMID 41034216›Full record

ArticleNature communications2025

HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato.

Ting Sun, Chaoyi Hu, Changan Zhu, Jiaxing Cai, Guoting Wang, Xiaojian Xia, Kai Shi, Yanhong Zhou, Jingquan Yu, Christine H Foyer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Genome-Wide Identification and Analysis of bZIP Transcription Factors inInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ting Sun *Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.
Chaoyi Hu *Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.
Changan Zhu *Department of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.
Jiaxing CaiDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.
Guoting WangDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.
Xiaojian XiaDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.
Kai ShiDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-5351-1910
Yanhong ZhouDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China. yanhongzhou@zju.edu.cn.ORCID http://orcid.org/0000-0002-7860-8847
Jingquan YuDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China. jqyu@zju.edu.cn.ORCID http://orcid.org/0000-0002-7626-1165
Christine H FoyerSchool of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, UK. c.h.foyer@bham.ac.uk.ORCID http://orcid.org/0000-0001-5989-6989
Jie ZhouDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou, China. jie@zju.edu.cn.ORCID http://orcid.org/0000-0002-8797-7214

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32020103013
6 · The paper itself

Abstract

Plants have evolved sophisticated defense systems to protect against herbivory, including the systemic induction of jasmonic acid (JA) synthesis. However, the molecular mechanisms underlying this process remain poorly understood. Here, we report that root-knot nematode (RKN) attack induced a phyB-dependent accumulation of ELONGATED HYPOCOTYL 5 (HY5) in the leaves, which activates the expression of JA biosynthesis genes and HY5 itself in tomato. In addition, the systemic transmission of GLUTAMATE RECEPTOR-LIKE 3.5 (GLR3.5)-dependent electrical signals induced by RKN triggers the physical interaction between CALMODULIN 2 (CaM2) and HY5 to amplify the transcriptional regulation of HY5 and JA synthesis. HY5 functions as a systemic signal that moves from leaves to roots to maintain the electrical signaling from roots to leaves by activating GLR3.5 expression. Together, these results reveal a HY5-dependent systemic signaling cascade that integrates light and electrical signals to activate JA-mediated defense against nematodes in tomato.

Indexed as

Basic-Leucine Zipper Transcription FactorsCyclopentanesOxylipinsPlant DiseasesPlant ProteinsSolanum lycopersicumAnimalsCalmodulinGene Expression Regulation, PlantLightNematodaPlant LeavesPlant RootsPlants, Genetically ModifiedSignal TransductionTylenchoideaBasic-Leucine Zipper Transcription FactorsCalmodulinCyclopentanesjasmonic acidOxylipinsPlant Proteins

Identifiers

PMID41034216
PMCPMC12489108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.