ArticleArthritis care & research2026
Diffusion-Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients.
Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Diagnostic Accuracy of Dual Energy CT for Bone Marrow Edema of the Sacroiliac Joints Compared with MRI: A Systematic Review.Journal of clinical medicine · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
objectiveMaturational signal in the sacroiliac joint (SIJ) of skeletally immature youth is often misinterpreted as inflammation. Diagnostic tools that improve specificity are greatly needed. Apparent diffusion coefficient (ADC) values from diffusion-weighted imaging (DWI), when used with standard imaging, may enhance diagnostic accuracy. We aimed to define normative pediatric ADC values and establish thresholds to distinguish normal from inflammatory SIJ signals.
methodsADC values were measured using circular regions of interest (ROIs) on the anterior, central, and posterior slices of the cartilaginous SIJs (36 total ROIs). Mean ADCs were analyzed by age group, bone (iliac or sacral), and joint height (superior, mid, inferior), accounting for within-patient clustering. In sacroiliitis cases, ROIs were placed on DWI at sites of increased signal on fluid-sensitive sequences. Thresholds differentiating normal and inflammatory signals were derived by age, bone, and joint height (ilium only) and assessed by area under the receiver operating characteristic (AUROC) and specificity.
resultsThe reference group included 86 youth. Inferior ilium ADC values were higher than mid and superior regions in all immature age groups (all P < 0.0001) and decreased with age (P = 0.0001). Sacral ADCs also declined with age (P = 0.0001). No age trend was observed in the superior or mid ilium (P = 0.14). ADC thresholds distinguished normal from inflammatory signals with AUROC ≥0.90 in most iliac regions, except the peripubertal inferior ilium (AUROC 0.78). Sacral thresholds performed acceptably (AUROC ≥ 0.77), though they were lower in the prepubertal group (AUROC 0.68).
conclusionAge- and bone-specific ADC reference values were established and effectively differentiated normal from inflammatory SIJ signals.
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