Evidence map›Paper›PMID 41034152›Full record

ArticleLife science alliance2025

Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes.

Nandaraj Taye, Stylianos Z Karoulias, Zerina Balic, Lauren W Wang, Belinda B Willard, Daniel Martin, Daniel Richard, Alexander S Okamoto, Terence D Capellini, Suneel S Apte and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Physiology (Bethesda, Md.) · 2026
    Review
  2. Identification of Genes Related to Rapid Growth of Giant Grouper (Animals : an open access journal from MDPI · 2025
    Article
  3. The Ubiquitin-Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nandaraj TayeOrthopedic Research Laboratories, Leni and Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stylianos Z KarouliasOrthopedic Research Laboratories, Leni and Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4177-1114
Zerina BalicOrthopedic Research Laboratories, Leni and Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lauren W WangDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Belinda B WillardProteomics and Metabolomics Core, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Daniel MartinDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.ORCID 0000-0002-3517-3716
Daniel RichardHuman Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Alexander S OkamotoHuman Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4630-7548
Terence D CapelliniHuman Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Suneel S ApteDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Dirk HubmacherOrthopedic Research Laboratories, Leni and Peter W. May Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA dirk.hubmacher@mssm.edu.ORCID 0000-0003-1569-9451

Funding

Regulation of Skeletal Growth by Soft Tissue Extracellular MatrixR01AR070748 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HUBMACHER, DIRK · 2017 to 2021
$1.9M
NIAMS NIH HHS R01 AR070748
6 · The paper itself

Abstract

Weill-Marchesani syndrome (WMS) is characterized by severe short stature, joint contractures, tight skin, heart valve and eye anomalies. WMS is caused by biallelic mutations in

Indexed as

ADAMTS ProteinsWeill-Marchesani SyndromeAnimalsChondrocytesCollagen Type VIDisease Models, AnimalExtracellular MatrixExtracellular Matrix ProteinsFibrillin-1FibroblastsFibronectinsHumansMiceMice, KnockoutPhenotypeSkinADAMTS ProteinsCollagen Type VIExtracellular Matrix ProteinsFibrillin-1Fibronectins

Identifiers

PMID41034152
PMCPMC12489390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.