Evidence map›Paper›PMID 41034131›Full record

ArticleThe Journal of veterinary medical science2025

Reverse genetics study disclaims the role of African swine fever virus gene I196L in the pathogenesis in pigs.

Ayumi Yoshimoto, Tomoya Kitamura, Mitsutaka Ikezawa, Takehiro Kokuho, Kentaro Masujin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ayumi YoshimotoExotic Disease Group, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), Tokyo, Japan.
Tomoya KitamuraExotic Disease Group, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), Tokyo, Japan.
Mitsutaka IkezawaExotic Disease Group, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), Tokyo, Japan.
Takehiro KokuhoExotic Disease Group, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), Tokyo, Japan.
Kentaro MasujinExotic Disease Group, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever virus (ASFV) genome encodes over 170 genes, but only a small number have been investigated for their roles in disease progression. Understanding the genetic and biological functions of these lesser-known genes accelerates the specification of open reading frames involved in pathogenesis in host animals and the development of ASF vaccines. In this study, we deleted the I196L gene of the highly virulent parental strain AQS-C-1-22 to generate the ASFV mutant AQSΔI196L. In vitro, AQSΔI196L replicated similarly to the parental virus in immortalized porcine kidney macrophage cultures. Pigs intramuscularly inoculated with 10

Indexed as

African Swine FeverAfrican Swine Fever VirusAnimalsReverse GeneticsSwineViremiaVirulenceVirus ReplicationAfrican swine fever virus (ASFV)I196L geneimmortalized porcine kidney macrophage (IPKM)vaccine

Identifiers

PMID41034131
PMCPMC12604949

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.