ArticleInternal medicine (Tokyo, Japan)2026
Ampicillin-dependent IgG Antibody Mediated Thrombocytopenia Confirmed Using Flow Cytometry.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Drug-induced immune thrombocytopenia (DITP) caused by ampicillin (ABPC) is rarely reported. An 87-year-old woman developed severe thrombocytopenia on postoperative day 3 during treatment with multiple drugs, including ABPC, for chronic periprosthetic infection following total knee arthroplasty. Although the platelet counts were unresponsive to oral prednisolone and intravenous immunoglobulin, they recovered promptly after the discontinuation of ABPC. Flow cytometry demonstrated ABPC-dependent IgG binding to healthy donor platelets. This is the first report to confirm ABPC-dependent platelet-reactive IgG using flow cytometry, thereby expanding the diagnostic tools for suspected DITP and highlighting the need for early recognition, prompt drug withdrawal, and appropriate supportive care.
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