Evidence map›Paper›PMID 41034004›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Diffuse Pulmonary Meningotheliomatosis Presenting with the Cheerios Sign Diagnosed by a Transbronchial Lung Cryobiopsy.

Tetsu Hirakawa, Kiyofumi Shimoji, Sachiko Shioya, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada and 1 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tetsu HirakawaDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Kiyofumi ShimojiDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Sachiko ShioyaDepartment of Internal Medicine, Mihara Medical Association Hospital, Japan.
Kakuhiro YamaguchiDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Shinjiro SakamotoDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Yasushi HorimasuDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Takeshi MasudaDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Taku NakashimaDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Hiroshi IwamotoDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Hironobu HamadaDepartment of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Noboru HattoriDepartment of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The "Cheerios sign" is a ring-shaped pulmonary nodule with central lucency, as observed on chest computed tomography. A 48-year-old woman with Turner syndrome presented with diffuse pulmonary nodules exhibiting the Cheerios sign. Although transbronchial lung biopsy is non-diagnostic, transbronchial lung cryobiopsy (TBLC) revealed nodules composed of meningothelial-like cells that were positive for epithelial membrane antigen, progesterone receptor, and CD56, thus leading to a diagnosis of diffuse pulmonary meningotheliomatosis. Estrogen and progesterone hormone therapy were discontinued, and the disease remained stable without treatment. This case highlights the diagnostic utility of TBLC for the evaluation of small pulmonary nodules that exhibit the Cheerios sign.

Indexed as

LungLung NeoplasmsBiopsyBronchoscopyCryosurgeryFemaleHumansMiddle AgedTomography, X-Ray Computedcheerios signdiffuse pulmonary meningotheliomatosismultiple minute meningothelial-like noduletransbronchial lung cryobiopsy

Identifiers

PMID41034004
PMCPMC13265106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.