Evidence map›Paper›PMID 41034002›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Methotrexate-associated Lymphoproliferative Disorder Showing Colon and Liver Lesions Difficult to Distinguish from Colon Cancer with Liver Metastases.

Kazuya Kanaya, Kensuke Kitsugi, Kanata Takahashi, Yuuto Arai, Kouhei Mori, Kai Sugitani, Kensuke Toyoda, Asako Shida, Akane Endo, Megumu Kouda and 8 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kazuya KanayaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Kensuke KitsugiDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Kanata TakahashiDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Yuuto AraiDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Kouhei MoriDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Kai SugitaniDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Kensuke ToyodaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Asako ShidaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Akane EndoDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Megumu KoudaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Ikumi IdaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Yousuke YamadaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Syuuhei UnnoDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Yousuke KobayashiDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Masaharu KimataDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Yashiro YoshizawaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Go MurohisaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.
Yoshisuke HosodaDepartment of Gastroenterology, Seirei Hamamatsu General Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 82-year-old man presented with weight loss was being treated with methotrexate (MTX) for rheumatoid arthritis. Computed tomography revealed sigmoid colonic wall thickening and multiple liver masses. Although we initially considered sigmoid colon cancer with liver metastases, the patient was diagnosed with MTX-associated lymphoproliferative disorder (MTX-LPD) based on histopathological findings and clinical course. All the lesions improved after MTX discontinuation. MTX-LPD rarely affects the gastrointestinal tract, particularly the colon. However, our case suggests that MTX-LPDs should be considered when gastrointestinal lesions are observed in patients receiving MTX.

Indexed as

Antirheumatic AgentsColonic NeoplasmsLiver NeoplasmsLymphoproliferative DisordersMethotrexateAged, 80 and overArthritis, RheumatoidDiagnosis, DifferentialHumansMaleAntirheumatic AgentsMethotrexatecolorectal cancerEpstein-Barr virus infectionslymphomarheumatoid arthritis

Identifiers

PMID41034002
PMCPMC13294605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.