ArticleInternal medicine (Tokyo, Japan)2026
Smear-positive Pulmonary Tuberculosis with False-negative Loop-mediated Isothermal Amplification and T-SPOT.TB Assays.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Rapid molecular and immunological assays for tuberculosis, including loop-mediated isothermal amplification (LAMP) and T-SPOT.TB assays, may yield false-negative results. We herein report a 62-year-old immunocompetent man with a productive cough, elevated C-reactive protein (22.8 mg/dL) and procalcitonin (2.7 ng/mL) levels, and computed tomography findings suggestive of nontuberculous mycobacterial infection. Despite the acid-fast bacilli-positive smears, two separate Mycobacterium tuberculosis LAMP assays and a T-SPOT.TB assay were negative. Empirical treatment with ampicillin/sulbactam and erythromycin improved the patient's condition. Four-week cultures confirmed pulmonary tuberculosis. This case underscores the importance of interpreting rapid assays within the clinical context and supports the use of reflex polymerase chain reaction for a definitive diagnosis.
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