Evidence map›Paper›PMID 41033989›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Small Cell Lung Cancer: A Dramatic Recovery after Chemotherapy.

Koichi Yano, Takuto Ishida, Kyoko Yokosuka, Kentaro Sakashita, Masafumi Mizuno

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Koichi YanoDepartment of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Japan.
Takuto IshidaDepartment of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Japan.
Kyoko YokosukaDepartment of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Japan.
Kentaro SakashitaDepartment of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Japan.
Masafumi MizunoDepartment of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for malignant tumors in patients with severe neurological conditions. We herein report a 66-year-old male who fell into a coma caused by anti-NMDAR encephalitis associated with small cell lung cancer (SCLC). Corticosteroid pulse therapy failed to improve his neurological condition, but a chemotherapy regimen containing atezolizumab led to rapid improvement in his condition. This case suggests that chemotherapy, including atezolizumab, may provide a rapid therapeutic benefit for anti-NMDAR encephalitis associated with SCLC.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisLung NeoplasmsSmall Cell Lung CarcinomaAgedAntibodies, Monoclonal, HumanizedHumansMaleTreatment OutcomeAntibodies, Monoclonal, Humanizedatezolizumabanti-NMDAR encephalitisatezolizumabchemotherapycomaparaneoplasticsmall-cell lung cancer

Identifiers

PMID41033989
PMCPMC13222693

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.