Evidence map›Paper›PMID 41033804›Full record

Trial reportThorax2026

Safety, feasibility and efficacy of exercise as an airway clearance technique in cystic fibrosis: a randomised pilot feasibility trial.

Don S Urquhart, Emily Taylor, Steve Cunningham, Steff Lewis, Aileen Rae Neilson, Dia Soilemezi, Hannah Ensor, Ioannis Vogiatzis, Lorna J Allen, Zoe Louise Saynor and 1 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05482048 (ExACT-CF), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05482048 naunknown statusnot on this map

ExACT-CF: Exercise as an Airway Clearance Technique in People With Cystic Fibrosis - A Randomised Pilot Trial

TypeinterventionalSponsorUniversity Hospital Southampton NHS Foundation TrustRan2023 to 2024Enrolled50ConditionsCystic FibrosisArmsExercise as Airway Clearance Therapy (ExACT)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Measurement of lung clearance index (LCIBMJ open respiratory research · 2026
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Don S UrquhartDepartment of Child Life and Health, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9048-9692
Emily TaylorDepartment of Child Life and Health, University of Edinburgh, Edinburgh, UK.
Steve CunninghamDepartment of Child Life and Health, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-7342-251X
Steff LewisEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Aileen Rae NeilsonEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Dia SoilemeziDepartment of Psychology, Sport and Exercise Sciences, University of Portsmouth, Portsmouth, UK.ORCID 0000-0001-8831-9419
Hannah EnsorEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Ioannis VogiatzisDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.ORCID 0000-0003-4830-7207
Lorna J AllenCystic Fibrosis Trust, London, UK.
Zoe Louise SaynorSchool of Health Sciences, University of Southampton, Southampton, UK Z.L.Saynor@soton.ac.uk.ORCID 0000-0003-0674-8477
ExACT-CF Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo test the feasibility and safety of exercise as an airway clearance technique (ExACT) for people with cystic fibrosis (pwCF) versus usual care (UC).

methodsDual-site, two-arm randomised pilot trial. Fifty pwCF (≥10 years, forced expiratory volume in 1 s (FEV

findingsExACT was safe over 28 days, measured by change in LCI DISCUSSION: Testing of our primary hypothesis within a feasibility trial showed ExACT to be a safe, acceptable and feasible intervention for pwCF. These data support advancement to a definitive, longer-term, multisite trial evaluating the safety, efficacy and cost-effectiveness of ExACT, following minor refinement. TRIAL REGISTRATION NUMBER: NCT05482048.

Indexed as

Cystic FibrosisExercise TherapyAdolescentAdultAminophenolsFeasibility StudiesFemaleForced Expiratory VolumeHumansMalePilot ProjectsQuality of LifeSpirometryTreatment OutcomeYoung AdultAminophenolsCystic FibrosisExercisePaediatric Lung DisaesePulmonary RehabilitationRespiratory Function Tests

Identifiers

PMID41033804
PMCPMC12911658

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.