Evidence map›Paper›PMID 41033605›Full record

ArticleTransplantation and cellular therapy2026

Identification of Distinct Subtypes in Immune Tolerance after Hematopoietic Cell Transplantation Using the Prospective ABLE1.0 Pediatric Study Cohort.

Bernard Ng, Andrew C Harris, Sayeh Abdossamadi, Madeline P Lauener, Geraldine Aubert, Rajinder Bajwa, Monica Bhatia, Henrique Bittencourt, Nataliya P Buxbaum, Emi H Caywood and 38 more

Abstract read
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In one paragraph

Article in Transplantation and cellular therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Bernard NgDepartment of Statistics, Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Andrew C HarrisMSK Kids Stem Cell Transplantation and Cellular Therapies, Memorial Sloan Kettering Cancer Center, New York, New York.
Sayeh AbdossamadiMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Madeline P LauenerMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Geraldine AubertRepeat Diagnostics Inc, North Vancouver, British Columbia, Canada.
Rajinder BajwaNationwide Children's Hospital Columbus, Ohio.
Monica BhatiaPediatric Stem Cell Transplant Program, Morgan Stanley Children's Hospital, Columbia University, New York, New York.
Henrique BittencourtPediatric Hematology-Oncology Division, Saint-Justine University Hospital Centre, Montreal, Quebec, Canada.
Nataliya P BuxbaumRoswell Park Comprehensive CancerCancer Center, Buffalo, New York.
Emi H CaywoodNemours Children's Health, Thomas Jefferson University, Wilmington, Delaware; Thomas Jefferson University, Philadelphia, Pennsylvania.
Sonali ChaudhuryHematology, Oncology, Neuro-Oncology & Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital, Northwestern University, Chicago, Illinois.
Joseph H ChewningDivision of Pediatric Hematology and Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
Sung Won ChoiUniversity of Michigan, Blood and Marrow Transplantation Program, Ann Arbor, Michigan.
Ashley ChopekManitoba Blood and Marrow Transplant Program, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.
Julia ChuPediatric Blood and Marrow Transplant Program, Benioff Children's Hospital, University of California San Francisco, San Francisco, California.
Donald CoulterDivision of Pediatric Hematology-Oncology, University of Nebraska Medical Center, Omaha, Nebraska.
Shahinaz M GadallaClinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Richard T HoggMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
David A JacobsohnDivision of Blood and Marrow Transplantation, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Amanda K JohnsonDivision of Pediatric Hematology, Oncology, and Bone Marrow Transplant. University of Utah/Primary Children's Hospital, Salt Lake City, Utah.
Michael JoyceNemours Children's Health, Jacksonville, Florida.
Kimberly A KasowPediatric Bone Marrow Transplant, University of North Carolina, Chapel Hill, North Carolina.
Michael KentAtrium Health/Levine Children's Charlotte, North Carolina.
Carrie L KitkoPediatric Stem Cell Transplant Program, Vanderbilt University Medical Center, Nashville, Tennessee.
Donna LauMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Anita LawitschkaStem Cell Transplant Unit, St. Anna Children's Hospital, Medical University, Vienna, Austria.
Victor A LewisPediatric Oncology and Transplant, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
Amanda M LiMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Laura McLaughlinChildren's Hospital Colorado Denver, Colorado.
David MitchellDivision of Pediatric Hematology-Oncology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
Eneida R NemecekPediatric Blood and Marrow Transplantation, Doernbecher Children's Hospital, Oregon Health and Sciences University, Portland, Oregon.
Vaishnavi ParthasarathyMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Allen Institute for Immunology, Seattle, Washington.
Anna B PawlowskaPediatric Hematology, Oncology and Hematopoietic Stem Cell Transplant. City of Hope, Duarte, California.
Filip PirslDivision of Blood and Marrow Transplantation, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Michael A PulsipherDivision of Pediatric Hematology, Oncology, and Bone Marrow Transplant. University of Utah/Primary Children's Hospital, Salt Lake City, Utah.
Muna QayedEmory University School of Medicine, Atlanta, Georgia.
Jacob RozmusMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Süreyya SavaşanPediatric Hematology & Oncology, Children's Hospital of Michigan, Detroit, Michigan.
Tal SchechterPediatric Hematology-Oncology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Shalini ShenoyWashington University School of Medicine, St. Louis, Missouri.
Alima SuleimenovaMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Dong Jun ZhengMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Elena OstroumovMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Ramon I Klein GeltinkDepartment of Pathology and Laboratory Medicine, University of British Columbia, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
Andrew GilmanICON Biotech, Center for Cell and Gene Therapy, Charlotte, North Carolina.
Daniel WolffDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Geoffrey D E CuvelierPediatric Oncology and Transplant, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
Kirk R SchultzMichael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: kschultz@mail.ubc.ca.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The lack of immune tolerance after hematopoietic cell transplantation (HCT) can result in chronic graft-versus-host disease (cGvHD), which is the primary nonrelapse limitation of successful HCT. To date, immune tolerance has been considered a single biological entity, but we hypothesized that post-HCT immune tolerance could develop through multiple pathways. Using the ABLE network database, which comprises measurements of 75 cell populations, 10 cytokines and chemokines, lymphocyte population telomere length, KRECs and TRECs, and 132 metabolites from the largest pediatric cGvHD cohort (n = 241), we applied clustering analysis to patients with primary immune tolerance (PIT; no acute GvHD [aGvHD] or cGvHD) and patients with secondary immune tolerance (SIT; previous aGvHD and no cGvHD) to test whether subtypes could be identified. The evaluation of PIT identified 3 subtypes. PIT-1, associated with postpubertal age, lower thymic output, and increased ST2 compared to PIT-2 and PIT-3, is effector memory T cell-predominant. PIT-2, associated with prepubertal age, normal thymic output, increased B cell development, and longer lymphocyte telomeres, has a naïve T cell-predominant pattern. PIT-3, associated with postpuberty, higher thymic output, and malignancy, is dominated by increased PD1

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationImmune ToleranceAdolescentChildChild, PreschoolCohort StudiesFemaleHumansInfantMaleProspective StudiesChronic GvHDHematopoietic cell transplantationImmune toleranceModeling immune patterns

Identifiers

PMID41033605
PMCPMC12958916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.