Trial reportJournal of advanced research2026
Evaluating intensive blood pressure control versus usual care on cardiovascular disease in patients with diabetes using win statistics: a subgroup analysis of a cluster randomized trial.
Trial report in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03527719 (Effectiveness of a Standardized Protocol-based Treatment Program on Hypertension Control in Rural China), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Standardized Protocol-based Treatment Program on Hypertension Control in Rural China
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Intensive blood pressure control in type 2 diabetes: a meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionElevated arterial pressure constitutes a significant controllable risk element associated with detrimental outcomes in cardiovascular health. In comparison to standard blood pressure (BP) control (target level: <140/90 mmHg), intensive blood pressure management aimed at achieving lower target values has demonstrated superior efficacy in diminishing the incidence of negative cardiovascular occurrences. However, there is still controversy over intensifying blood pressure control in diabetic individuals.
objectivesAssessing the viability and efficacy of stringent blood pressure regulation in diabetic patients with hypertension.
methodsA post hoc analysis of disaggregated data from 33,995 hypertensive patients enrolled in the China Rural Hypertension Control Project (CRHCP) trial was performed. Outcomes were evaluated using the unmatched win ratio (win ratio >1.00 indicating better outcomes) and compared with the Cox model. The principal endpoint was the occurrence of major adverse cardiovascular events (MACE), encompassing myocardial infarction, stroke, hospitalization due to heart failure, or cardiovascular mortality, over a three-year follow-up period.
resultsThe analysis included 6303 adults with hypertension and diabetes (mean age 63.2 years; 2172 men). At the three-year mark, the average systolic/diastolic blood pressure measured 126.7/72.5 mmHg in the intensive blood pressure control cohort, in contrast to 147.7/80.6 mmHg in the standard care group. Intensive blood pressure management lowered the yearly incidence of major adverse cardiovascular events (MACE, 2.28 % compared to 3.28 %; HR: 1.45; 95 % CI: 1.20-1.72; P < 0.001), strokes (HR: 1.47; 95 % CI: 1.20-1.82; P = 0.015), and deaths from cardiovascular causes (HR: 1.49; 95 % CI: 1.04-2.13; P = 0.029). Symptomatic hypotension rates were similar (0.77 % vs. 0.52 %; P = 0.231). Hierarchical analysis showed more wins (31021 [8.62 %]) than losses (23985 [5.84 %]), with a win ratio of 1.46 (95 % CI: 1.22-1.76; P < 0.001). After 36 months, the mean fasting blood glucose (FBG) in the group with intensified blood pressure control was modestly elevated (9.09 mmol/L compared to 8.51 mmol/L; difference: 0.58 mmol/L; 95 % CI: 0.34-0.81; P < 0.001).
conclusionIntensive BP controlled by non-physician community healthcare providers reduced incident cardiovascular diseases in hypertensive patients with comorbid diabetes but was associated with an elevation of FBG. REGISTRATION: The trial is listed on ClinicalTrials.gov under the identifier NCT03527719.
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