Observational studyArchives of physical medicine and rehabilitation2026
Microdialysis Evaluation of Blood Flow, Lactate, and Glucose in Active Trigger Points of Tension-Type Headache Patients and Latent Trigger Points in Healthy Muscle.
Observational study in Archives of physical medicine and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Fascia as a Functional System in Health and Disease: From Fundamental Biology to Assessment and Targeted Interventions.International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo assess nutritive blood flow, lactate, and glucose within active and latent trigger points (TrPs) compared with non-TrP muscle.
designCase-controlled observational study.
settingA university-based clinical and translational research center.
participantsActive TrPs were identified through palpation of the upper trapezius muscle of individuals with episodic or chronic tension-type headache (TTH). Latent TrPs and muscle without TrPs were identified in age- and sex-matched subjects without a history of headache. A total of 64 individuals participated in the study.
interventionsNot applicable.
main outcome measuresNutritive blood flow, and interstitial lactate and glucose concentrations were determined at 12-20 minutes intervals over 160 minutes through microdialysis sampling of interstitial fluid.
resultsSubjects were 33.8±10.8 years, 64.1% women, and 73.4% white, with no statistical differences between active, latent, and no TrP groups on demographic or baseline variables (P>.05). Subjects with TTH reported a median of 4 headaches/mo and had experienced headaches for a median of 120 months. Active TrPs exhibit higher nutritive blood flow than anatomically matched no TrP muscle (P=.026) but were not different from latent TrPs (P=.554). There were no global differences between the 3 groups for lactate (P=.329) or glucose (P=.231).
conclusionsThis study provides in vivo evidence of higher nutritive blood flow in active TrPs from individuals with TTH but no difference in lactate and glucose compared with non-TrP muscle. Our data do not support the TrP as a tightly contracted, ischemic region within skeletal muscle. Interventions designed to relax muscle contraction or increase blood flow may have limited benefits in alleviating active trigger points.
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