Evidence map›Paper›PMID 41033358›Full record

ArticleToxicology and applied pharmacology2025

Arsenic exposure affects Pdgfrα stromal cells in the ileum of the small intestine.

Scott W Ventrello, Kayla A Lea, Lisa J Bain

Erratum issuedAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Scott W VentrelloDepartment of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA.
Kayla A LeaDepartment of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA.
Lisa J BainDepartment of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA. Electronic address: lbain@clemson.edu.

Funding

Arsenic's effects on the intestinal stem cell nicheR15ES031766 · NIEHS · CLEMSON UNIVERSITY · PI BAIN, LISA J · 2021 to 2021
$442k
NIEHS NIH HHS R15 ES031766
6 · The paper itself

Abstract

Arsenic is a contaminant in drinking water and food, and exposure induces inflammation and barrier disruption in the small intestine and colon. Further, arsenic can alter stromal cell numbers and their signaling molecules in the duodenum. Thus, the goal of this study was to investigate arsenic's effects on morphology, Pdgfrα

Indexed as

ArsenicIleumReceptor, Platelet-Derived Growth Factor alphaStromal CellsAnimalsDose-Response Relationship, DrugFemaleMaleMiceMice, Inbred C57BLTelocytesArsenicReceptor, Platelet-Derived Growth Factor alphaArsenicFgfr2+ fibroblastStromal cellsTelocyteTrophocyteWnt4

Identifiers

PMID41033358
PMCPMC13459434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.