Evidence map›Paper›PMID 41033124›Full record

ArticlePlacenta2025

Gestational fine particulate matter exposures and spontaneous preterm birth: Elucidating mechanisms using placental transcriptome and metabolome signatures.

Jagadeesh Puvvula, Aimin Chen, Rebecca Simmons, Rita Leite, Yu-Chin Lien

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jagadeesh PuvvulaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jagadeesh.puvvula@pennmedicine.upenn.edu.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA, USA.
Rebecca SimmonsCenter for Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Center for Women's Health and Reproductive Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rita LeiteCenter for Women's Health and Reproductive Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yu-Chin LienCenter for Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Center for Women's Health and Reproductive Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: ylien@pennmedicine.upenn.edu.

Funding

Philadelphia Regional Center for Children’s Environmental HealthP2CES033428 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Aimin Chen, Marilyn Howarth · 2022 to 2026
$5.4M
NIEHS NIH HHS P2C ES033428
6 · The paper itself

Abstract

backgroundThis study aims to evaluate the mediating role of placental transcriptomic and metabolomic changes in the association between gestational exposure to fine particulate matter and spontaneous preterm birth (sPTB).

methodsThis study includes 72 participants from the CellulaR Injury and Preterm Birth Study. Daily exposure to PM

resultsBlack carbon exposure during gestational months 3-5 was associated with increased odds of sPTB. We identified 63 genes linked to black carbon and 50 to PM

conclusionGestational exposure to black carbon is associated with increased odds of sPTB, and this association was mediated by altered placental gene expression.

Indexed as

Maternal ExposureMetabolomeParticulate MatterPlacentaPremature BirthTranscriptomeAdultFemaleHumansPregnancySootParticulate MatterSootFine particulate matterMetabolomeMultiple mediationSpontaneous preterm birthTranscriptome

Identifiers

PMID41033124
PMCPMC13058859

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.