Evidence map›Paper›PMID 41033085›Full record

ReviewThe Journal of pharmacology and experimental therapeutics2025

Store-operated calcium entry-based targets for novel cancer therapeutic development.

Moana E Hala'ufia, David L Roman

Abstract readReview
In one paragraph

Review in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dual modulation of intracellular CaJournal of molecular histology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Moana E Hala'ufiaDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, Iowa; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
David L RomanDepartment of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, Iowa; Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa. Electronic address: david-roman@uiowa.edu.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Predoctoral Training in the Pharmacological SciencesT32GM067795 · NIGMS · UNIVERSITY OF IOWA · PI STRACK, STEFAN · 2004 to 2021
$3.4M
NCI NIH HHS P30 CA086862NIGMS NIH HHS T32 GM067795
6 · The paper itself

Abstract

Store-operated calcium entry (SOCE) is the major mechanism for cellular calcium homeostasis that is ubiquitous across cell types and is responsible for replenishing Ca

Indexed as

Antineoplastic AgentsCalciumDrug DevelopmentNeoplasmsAnimalsCalcium ChannelsCalcium SignalingHumansMolecular Targeted TherapyORAI1 ProteinStromal Interaction Molecule 1Antineoplastic AgentsCalciumCalcium ChannelsORAI1 ProteinORAI1 protein, humanStromal Interaction Molecule 1Protein-protein interactionStore-operated calcium entryTargeted drug developmentTriple negative breast cancer

Identifiers

PMID41033085
PMCPMC13095634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.