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ArticleJMIR aging2025

An mHealth App (NeoMayor) to Promote Healthy Lifestyles and Brain Health in Older Adults: Design and Validation Study.

Myriam Gutiérrez, Victoria Cabello, Carol D SanMartín, Jorge Mauro, Gada Musa, Melissa Torres, Maria Consuelo San Martin, Carlos Márquez, Rodrigo Beltrán, Nicole Rogers and 13 more

Registry-linked trialAbstract readValidation Study
In one paragraph

Article in JMIR aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07633392 (A Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial of NeoMayor, a Mobile Health Intervention to Improve Cardiovascular Health in Chilean Older Adults), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07633392 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial of NeoMayor, a Mobile Health Intervention to Improve Cardiovascular Health in Chilean Older Adults

TypeinterventionalSponsorUniversity of ChileRan2026 to 2027Enrolled240ConditionsCardiovascular Health Status, Smoking Status, Physical Activity, Diet QualityArmsNeoMayor App, Wearable Device Support, Human Health Coach Support
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Myriam Gutiérrez *Unidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-8742-0363
Victoria Cabello *Unidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-2301-7406
Carol D SanMartínCentro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-3733-5448
Jorge MauroFacultad de Salud y Odontología, Escuela de Kinesiología, Universidad Diego Portales, Santiago, Chile.ORCID https://orcid.org/0000-0001-5414-5860
Gada MusaUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-2660-6046
Melissa TorresUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0000-4130-7234
Maria Consuelo San MartinUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-6999-6908
Carlos MárquezUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-8166-8605
Rodrigo BeltránUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0004-1921-8031
Nicole RogersFacultad de Medicina, Departamento de Neurociencia, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-1812-6416
Felipe SalechFacultad de Medicina, Departamento de Neurociencia, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-1575-7658
Daniela PonceCentro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0009-0426-2562
Christian AmpueroWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0008-9077-4283
Pia VarasWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0008-0140-1531
Bastián Gamboa-LabbéWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-3097-0078
Víctor David CortésWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-6983-8272
Carlos VegaWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0002-4633-0008
Rocío RuizWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-7730-174X
Juan VelásquezWeb Intelligence Centre (WIC), Departamento de Ingeniería Industrial, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-4819-9680
Rodrigo VergaraDepartamento de Kinesiología, Facultad de Artes y Educación Física, Universidad Metropolitana de Ciencias de la Educación, Santiago, Chile.ORCID https://orcid.org/0000-0002-1943-2060
Maria Isabel BehrensCentro de Investigación Clínica Avanzada (CICA), Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-0964-426X
Jamileth MoreUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-2071-1868
Carolina Delgado DerioUnidad de Cerebro Saludable, Hospital Clínico Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-5551-0065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Latin American countries, the prevalence of noncommunicable diseases has increased rapidly in recent decades. Mobile health (mHealth) apps are now widely available at low cost and are easy to implement, offering an opportunity to encourage healthy lifestyles in older adults. However, at present, there are no mHealth apps that integrate multidomain healthy lifestyle interventions specifically adapted for older adults in Chile.

objectiveThis study aims to describe the development and validation of NeoMayor, an mHealth app designed to promote healthy lifestyles as well as cardiovascular and brain health in older adults in Chile.

methodsNeoMayor was developed iteratively with feedback from users and input from a multidisciplinary team of clinicians, researchers, and software developers. Using lean user experience methodology, we ensured user involvement throughout the design and validation process. The research was conducted in 2 phases. In the design and development phase, we created and adapted evidence-based recommendations. In the validation phase, we conducted a pilot study to assess usability, adherence, and cardiovascular health (CVH). A total of 60 functionally independent and cognitively healthy participants used the NeoMayor app for 2 months. Clinical and cognitive assessments were conducted before and after app use. We held 26 cocreation sessions with users, consulted experts, performed a literature review, and collaborated with a team of app developers to create a functional prototype.

resultsThe mean age of the participants was 71 (SD 15) years, and 85% (51/60) were female. Participants had an average of 9.8 (SD 3.6) years of education. At the end of the 2-month intervention, usability testing indicated high engagement and adherence, with participants using the app for an average of 6.6 (SD 11.85) minutes per day twice a week. Improvements were observed in global CVH, with the mean Life's Essential 8 CVH index score increasing from 64 (SD 10) to 68 (SD 11; P<.001). Reductions were noted in systolic blood pressure (10 mm Hg) and waist circumference (7 cm), along with increased high-density lipoprotein cholesterol levels. Participants also showed improvements in self-reported physical activity and diet, higher scores on the Short Physical Performance Battery, and faster performance times on the sit-to-stand and gait speed tests. The app was optimized for broad compatibility with Android devices, safe data collection and storage, and compliance with data privacy regulations following good clinical practices. The final product is ready for testing in a randomized controlled trial.

conclusionsThis study represents the first initiative in Chile to develop and validate an mHealth app to promote healthy lifestyles as well as cardiovascular and brain health in older adults, offering an effective, accessible, and affordable solution for promoting healthy aging in Latin American countries.

Indexed as

BrainHealth PromotionHealthy LifestyleMobile ApplicationsAgedAged, 80 and overChileFemaleHumansMaleMiddle AgedPilot ProjectsTelemedicinebrain healthdementia preventionhealthy agingmHealthmobile healthnoncommunicable diseases

Identifiers

PMID41032870
PMCPMC12530159

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.