Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control.

Marc Mora, Georgia Cohen, William Cranton, Olaia Anton, Amy E M Beedle, Guillaume Stirnemann, Sergi Garcia-Manyes

Abstract read

In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marc MoraDepartment of Physics, Randall Centre for Cell and Molecular Biophysics, Centre for the Physical Science of Life and London Centre for Nanotechnology, King's College London, Strand, London WC2R 2LS, U.K.

Georgia CohenDepartment of Physics, Randall Centre for Cell and Molecular Biophysics, Centre for the Physical Science of Life and London Centre for Nanotechnology, King's College London, Strand, London WC2R 2LS, U.K.

William CrantonDepartment of Physics, Randall Centre for Cell and Molecular Biophysics, Centre for the Physical Science of Life and London Centre for Nanotechnology, King's College London, Strand, London WC2R 2LS, U.K.

Olaia AntonCPCV, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne University, CNRS, 75005 Paris France.

Amy E M BeedleDepartment of Physics and Centre for the Physical Science of Life, King's College London, Strand, London WC2R 2LS, U.K.

Guillaume StirnemannCPCV, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne University, CNRS, 75005 Paris France.ORCID 0000-0002-5631-5699

Sergi Garcia-ManyesDepartment of Physics, Randall Centre for Cell and Molecular Biophysics, Centre for the Physical Science of Life and London Centre for Nanotechnology, King's College London, Strand, London WC2R 2LS, U.K.ORCID 0000-0001-5140-2606

Funding

Wellcome Trust CC0102

6 · The paper itself

Abstract

In addition to thermal energy, current, and light, mechanical forces activate chemical reactions, often steering reaction pathways that result in products different from those obtained under thermodynamic control. Single-molecule mechanochemistry experiments have probed how the forced activation of a single covalent bond results in accelerated scission of both homolytic and heterolytic bonds, and the ring-opening of strained mechanophores in long polymers. Due to its mechanistic simplicity, the concerted S

Identifiers

PMID41032857

DOI10.1021/jacs.5c13084

PMCPMC12532186

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.