In one paragraphArticle in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
28 authors.
Constance A OwensDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0001-7208-394X Ethan B LudmirDepartment of Gastrointestinal Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-5472-5344 Weiyu QiuDepartment of Public Health Sciences, University of Alberta, Edmonton, AB, Canada.
Aashish C GuptaDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-0178-0921 Susan A SmithDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-6367-3080 Bastien RigaudDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Kristy K BrockDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0001-9364-5040 James E BatesDepartment of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA.ORCID 0000-0001-7060-7156 Taylor G MeyersDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0009-0000-3332-7155 Arnold C PaulinoDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Christine B PetersonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0003-3316-0468 Stephen F KryDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0001-6899-197X Cécile M RonckersDivision of Childhood Cancer Epidemiology (EpiKiK), Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0003-3524-4657 Wendy M LeisenringClinical and Public Health Sciences Divisions, Fred Hutchinson Cancer Center, Seattle, WA.ORCID 0000-0001-7405-0906 Paul C NathanDivision of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0001-7460-8578 Chaya S MoskowitzDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-2850-8450 Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.
Yutaka YasuiDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-7717-8638 Rebecca M HowellDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MMach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7MNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA021765NCI NIH HHS U24 CA055727
6 · The paper itselfAbstract
purposeAmong childhood cancer survivors, we evaluated not previously explored relationships between colorectal subsequent malignant neoplasm (SMN) incidence and colorectum-specific radiation dose metrics currently used in radiation therapy (RT) planning and expanded upon previously reported chemotherapy associations.
methodsThe Childhood Cancer Survivor Study (CCSS) includes 5-year survivors of childhood cancer diagnosed between 1970 and 1999. RT was assessed as mean colorectal dose (MCD) and the percent volume (V
resultsAmong 25,723 survivors (median follow-up = 28.5 years; range = 5.0-48.9), 104 colorectal SMNs were identified. A dose-response relationship was observed between MCD and colorectal SMN rates; incidence rate ratios (IRRs) for 10 to <20 Gy and ≥20 Gy were 3.6 (95% CI, 1.9 to 6.9) and 8.3 (95% CI, 3.9 to 17.8), respectively. When ≥20% of the colorectum volume was irradiated, IRRs increased with increasing volume. The V
conclusionThese RT and chemotherapy dose-response relationships can better inform contemporary RT planning for pediatric patients and surveillance guidelines for high-risk survivors.
Indexed as
Cancer SurvivorsColorectal NeoplasmsNeoplasms, Radiation-InducedNeoplasms, Second PrimaryAdolescentAdultChildChild, PreschoolDose-Response Relationship, RadiationFemaleHumansIncidenceInfantMaleRadiotherapy DosageYoung Adult
Identifiers
PMID41032739
PMCPMC12573684
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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