Evidence map›Paper›PMID 41032627›Full record

ArticleScience translational medicine2025

An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques.

L K Metthew Lam, Theron Gilliland, Matthew Dunn, Maria D Alcorn-Burckhardt, Yutaka Terada, Chengqun Sun, Shauna Vasilatos, Morgan Midgett, Connor Williams, Amanda Laughlin and 11 more

Abstract read
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

L K Metthew LamCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-9700-4988
Theron GillilandCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8373-0057
Matthew DunnCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-0378-5838
Maria D Alcorn-BurckhardtCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-8211-3647
Yutaka TeradaCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Chengqun SunCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Shauna VasilatosCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0003-2688-1571
Morgan MidgettCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Connor WilliamsCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0007-5315-6964
Amanda LaughlinCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0002-4285-2108
Jeneveve LundyCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Christina L GardnerVirology Division, United States Army Military Institute for Infectious Diseases, Frederick, MD 21702, USA.ORCID 0000-0002-3475-8966
Archana ThomasOregon Health & Science University, Beaverton, OR 97006, USA.ORCID 0000-0002-5943-5004
Hans-Peter RauéOregon Health & Science University, Beaverton, OR 97006, USA.
Hans P GertjeNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA.
Aoife K O'ConnellNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA.
Nicholas A CrosslandNational Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA.ORCID 0000-0003-3873-9188
Douglas S ReedCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-0076-9023
Michael S DiamondDepartments of Medicine, Molecular Microbiology, Pathology and Immunology and the Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8791-3165
Mark K SlifkaOregon Health & Science University, Beaverton, OR 97006, USA.ORCID 0000-0001-8205-6136
William B KlimstraCenter for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4506-7842

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
An Informed Approach to Live Attenuated Vaccines against Encephalitis AlphavirusesR01AI153209 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLIMSTRA, WILLIAM B · 2020 to 2024
$2.9M
Vectra Polaris Quantitative Pathology Imaging SystemS10OD030269 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2021 to 2021
$402k
NIAID NIH HHS R01 AI153209NIH HHS P51 OD011092NIH HHS S10 OD030269
6 · The paper itself

Abstract

Venezuelan (VEEV), Eastern (EEEV), and Western (WEEV) equine encephalitis viruses are mosquito-transmitted alphaviruses in the family

Indexed as

AlphavirusAlphavirus InfectionsVaccines, InactivatedViral VaccinesVirionAerosolsAnimalsAntibodies, ViralEncephalitis Virus, Venezuelan EquineFemaleMacacaMiceAerosolsAntibodies, ViralVaccines, InactivatedViral Vaccines

Identifiers

PMID41032627
PMCPMC13019386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.