Evidence map›Paper›PMID 41032244›Full record

ArticleOrganic letters2025

Generation [via Tetradehydro-Diels-Alder Reactions] and Reactivity of 6-Fluorocyclohexa-1,2,4-triene Intermediates.

Paul V Kevorkian, Thomas R Hoye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paul V KevorkianDepartment of Chemistry, University of Minnesota, 207 Pleasant Street, SE, Minneapolis, Minnesota 55455, United States.
Thomas R HoyeDepartment of Chemistry, University of Minnesota, 207 Pleasant Street, SE, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-9318-1477

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
Synthesis, Structure, and Mechanism of Biorelevant Molecules and ReactionsR35GM127097 · NIGMS · UNIVERSITY OF MINNESOTA · PI THOMAS R. HOYE · 2018 to 2026
$3.5M
Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical ResearchS10OD011952 · OD · UNIVERSITY OF MINNESOTA · PI HOYE, THOMAS R. · 2012 to 2012
$378k
NCI NIH HHS P30 CA077598NIGMS NIH HHS R35 GM127097NIH HHS S10 OD011952
6 · The paper itself

Abstract

We report the engagement of the 2,6-difluorophenyl substituent in tetradehydro-Diels-Alder (TDDA) reactions. The use of fluorine was guided by DFT computations. Acceleration of TDDA cycloisomerization by an anhydride linker in the substrates was also key. Trapping of the strained cyclic allene intermediate by nucleophilic carbons in external heterocycles, an enol, and alkenes led to unusual reactivities (e.g., one rationalized by rearrangement to a carbene intermediate).

Identifiers

PMID41032244
PMCPMC12520193

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.